Downregulated mRNA Expression of ZNF385B Is an Independent Predictor of Breast Cancer
Background. ZNF385B, a zinc finger protein, has been known as a potential biomarker in some neurological and hematological studies recently. Although numerous studies have demonstrated the potential function of zinc finger proteins in tumor progression, the effects of ZNF385B in breast cancer (BC) a...
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doaj-a4602525d6ae479096bf31b536420ea32021-02-15T12:52:56ZengHindawi LimitedInternational Journal of Genomics2314-436X2314-43782021-01-01202110.1155/2021/43018024301802Downregulated mRNA Expression of ZNF385B Is an Independent Predictor of Breast CancerNing Yan0Cong Liu1Fang Tian2Ling Wang3Yimin Wang4Zhaoying Yang5Yan Jiao6Miao He7Department of Breast Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, ChinaDepartment of Breast Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, ChinaDepartment of Breast Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, ChinaDepartment of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, Jilin 130022, ChinaScientific Research Center, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, ChinaDepartment of Breast Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, ChinaDepartment of Anesthesia, The Second Hospital of Jilin University, Changchun, Jilin 130022, ChinaBackground. ZNF385B, a zinc finger protein, has been known as a potential biomarker in some neurological and hematological studies recently. Although numerous studies have demonstrated the potential function of zinc finger proteins in tumor progression, the effects of ZNF385B in breast cancer (BC) are less studied. Methods. The Oncomine database and “ESurv” tool were used to explore the differential expression of ZNF385B in pan-cancer. Furthermore, data of patients with BC were downloaded from The Cancer Genome Atlas (TCGA). The receiver operating characteristic (ROC) curve of ZNF385B expression was established to explore the diagnostic value of ZNF385B and to obtain the cut-off value of high or low ZNF385B expression in BC. The chi-square test as well as Fisher exact test was used for identification of the relationships between clinical features and ZNF385B expression. Furthermore, the effects of ZNF385B on BC patients’ survival were evaluated by the Kaplan-Meier and Cox regression. Data from the Gene Expression Omnibus (GEO) database were employed to validate the results of TCGA. Protein expression of ZNF385B in BC patient specimens was detected by immunohistochemistry (IHC) staining. Results. ZNF385B expression was downregulated in most types of cancer including BC. Low ZNF385B expression was related with survival status, overall survival (OS), and recurrence of BC. ZNF385B had modest diagnostic value, which is indicated by the area under the ROC curve (AUC=0.671). Patients with lower ZNF385B expression had shorter OS and RFS (relapse-free survival). It had been demonstrated that low ZNF385B expression represented independent prognostic value for OS and RFS by multivariate survival analysis. The similar results were verified by datasets from the GEO database as well. The protein expression of ZNF385B was decreased in patients’ samples compared with adjacent tissues by IHC. Conclusions. Low ZNF385B expression was an independent predictor for worse prognosis of BC patients.http://dx.doi.org/10.1155/2021/4301802 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ning Yan Cong Liu Fang Tian Ling Wang Yimin Wang Zhaoying Yang Yan Jiao Miao He |
spellingShingle |
Ning Yan Cong Liu Fang Tian Ling Wang Yimin Wang Zhaoying Yang Yan Jiao Miao He Downregulated mRNA Expression of ZNF385B Is an Independent Predictor of Breast Cancer International Journal of Genomics |
author_facet |
Ning Yan Cong Liu Fang Tian Ling Wang Yimin Wang Zhaoying Yang Yan Jiao Miao He |
author_sort |
Ning Yan |
title |
Downregulated mRNA Expression of ZNF385B Is an Independent Predictor of Breast Cancer |
title_short |
Downregulated mRNA Expression of ZNF385B Is an Independent Predictor of Breast Cancer |
title_full |
Downregulated mRNA Expression of ZNF385B Is an Independent Predictor of Breast Cancer |
title_fullStr |
Downregulated mRNA Expression of ZNF385B Is an Independent Predictor of Breast Cancer |
title_full_unstemmed |
Downregulated mRNA Expression of ZNF385B Is an Independent Predictor of Breast Cancer |
title_sort |
downregulated mrna expression of znf385b is an independent predictor of breast cancer |
publisher |
Hindawi Limited |
series |
International Journal of Genomics |
issn |
2314-436X 2314-4378 |
publishDate |
2021-01-01 |
description |
Background. ZNF385B, a zinc finger protein, has been known as a potential biomarker in some neurological and hematological studies recently. Although numerous studies have demonstrated the potential function of zinc finger proteins in tumor progression, the effects of ZNF385B in breast cancer (BC) are less studied. Methods. The Oncomine database and “ESurv” tool were used to explore the differential expression of ZNF385B in pan-cancer. Furthermore, data of patients with BC were downloaded from The Cancer Genome Atlas (TCGA). The receiver operating characteristic (ROC) curve of ZNF385B expression was established to explore the diagnostic value of ZNF385B and to obtain the cut-off value of high or low ZNF385B expression in BC. The chi-square test as well as Fisher exact test was used for identification of the relationships between clinical features and ZNF385B expression. Furthermore, the effects of ZNF385B on BC patients’ survival were evaluated by the Kaplan-Meier and Cox regression. Data from the Gene Expression Omnibus (GEO) database were employed to validate the results of TCGA. Protein expression of ZNF385B in BC patient specimens was detected by immunohistochemistry (IHC) staining. Results. ZNF385B expression was downregulated in most types of cancer including BC. Low ZNF385B expression was related with survival status, overall survival (OS), and recurrence of BC. ZNF385B had modest diagnostic value, which is indicated by the area under the ROC curve (AUC=0.671). Patients with lower ZNF385B expression had shorter OS and RFS (relapse-free survival). It had been demonstrated that low ZNF385B expression represented independent prognostic value for OS and RFS by multivariate survival analysis. The similar results were verified by datasets from the GEO database as well. The protein expression of ZNF385B was decreased in patients’ samples compared with adjacent tissues by IHC. Conclusions. Low ZNF385B expression was an independent predictor for worse prognosis of BC patients. |
url |
http://dx.doi.org/10.1155/2021/4301802 |
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