Effect of Camphor on Pituitary-Gonadal Hormonal Axis and Oogenesis in Adult Female Rats
Background & Objective: Camphor stimulates the nervous system and the circulatory system, reduces lactation, and prevents conception and embryo embedding. We investigated the effects of camphor on the pituitary-gonadal hormonal axis and concentration of steroidal hormones. Materials & Meth...
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Fasa University of Medical Sciences
2013-06-01
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doaj-a4641644a5c64a1888a0ad3ea0c169942020-11-24T21:59:20ZfasFasa University of Medical SciencesJournal of Fasa University of Medical Sciences2228-51052228-73292013-06-01316974Effect of Camphor on Pituitary-Gonadal Hormonal Axis and Oogenesis in Adult Female RatsHabibollah JohariAmir Ashkan MahjoorSiyamak FallahiHossein Kargar JahromiMaryam AbediniMohammad Ali Poor DaneshZahra ZamaniBackground & Objective: Camphor stimulates the nervous system and the circulatory system, reduces lactation, and prevents conception and embryo embedding. We investigated the effects of camphor on the pituitary-gonadal hormonal axis and concentration of steroidal hormones. Materials & Methods: The parameters investigated were concentrations of LH, FSH, estrogen, progesterone, and testosterone. Forty adult female rats at a mean weight of 180 ± 20 grams were divided into five groups. Camphor solution was prepared in olive oil at 25, 50, and 100 mg/kg doses, and 0.2 cc injections were done intraperitoneally every day for 2 weeks. The control group received no injection. The sham group received olive oil (as solvent of camphor) and treatment groups of 1, 2, and 3 received doses of 25, 50, and 100 mg/kg. The treatment groups were sacrificed one day after the last injection, and their hearts were dissected and blood samples were obtained. The concentrations of the hormones were measured by the ELISA test, and the results were evaluated via the t-test, ANOVA, and Duncan. Results: The results showed a significant decrease in the concentrations of testosterone and progesterone (p value < 0.05) and a significant increase in the concentrations of LH and FSH (p value <0.05). Conclusion: Camphor augmented oogenesis via effecting a rise in the concentrations of LH and FSH in our rats. http://journal.fums.ac.ir/browse.php?a_code=A-10-26-33&slc_lang=en&sid=1CamphorOogenesisLHFSHTestosteroneRat |
collection |
DOAJ |
language |
fas |
format |
Article |
sources |
DOAJ |
author |
Habibollah Johari Amir Ashkan Mahjoor Siyamak Fallahi Hossein Kargar Jahromi Maryam Abedini Mohammad Ali Poor Danesh Zahra Zamani |
spellingShingle |
Habibollah Johari Amir Ashkan Mahjoor Siyamak Fallahi Hossein Kargar Jahromi Maryam Abedini Mohammad Ali Poor Danesh Zahra Zamani Effect of Camphor on Pituitary-Gonadal Hormonal Axis and Oogenesis in Adult Female Rats Journal of Fasa University of Medical Sciences Camphor Oogenesis LH FSH Testosterone Rat |
author_facet |
Habibollah Johari Amir Ashkan Mahjoor Siyamak Fallahi Hossein Kargar Jahromi Maryam Abedini Mohammad Ali Poor Danesh Zahra Zamani |
author_sort |
Habibollah Johari |
title |
Effect of Camphor on Pituitary-Gonadal Hormonal Axis and Oogenesis in Adult Female Rats |
title_short |
Effect of Camphor on Pituitary-Gonadal Hormonal Axis and Oogenesis in Adult Female Rats |
title_full |
Effect of Camphor on Pituitary-Gonadal Hormonal Axis and Oogenesis in Adult Female Rats |
title_fullStr |
Effect of Camphor on Pituitary-Gonadal Hormonal Axis and Oogenesis in Adult Female Rats |
title_full_unstemmed |
Effect of Camphor on Pituitary-Gonadal Hormonal Axis and Oogenesis in Adult Female Rats |
title_sort |
effect of camphor on pituitary-gonadal hormonal axis and oogenesis in adult female rats |
publisher |
Fasa University of Medical Sciences |
series |
Journal of Fasa University of Medical Sciences |
issn |
2228-5105 2228-7329 |
publishDate |
2013-06-01 |
description |
Background & Objective: Camphor stimulates the nervous system and the circulatory system, reduces lactation, and prevents conception and embryo embedding. We investigated the effects of camphor on the pituitary-gonadal hormonal axis and concentration of steroidal hormones. Materials & Methods: The parameters investigated were concentrations of LH, FSH, estrogen, progesterone, and testosterone. Forty adult female rats at a mean weight of 180 ± 20 grams were divided into five groups. Camphor solution was prepared in olive oil at 25, 50, and 100 mg/kg doses, and 0.2 cc injections were done intraperitoneally every day for 2 weeks. The control group received no injection. The sham group received olive oil (as solvent of camphor) and treatment groups of 1, 2, and 3 received doses of 25, 50, and 100 mg/kg. The treatment groups were sacrificed one day after the last injection, and their hearts were dissected and blood samples were obtained. The concentrations of the hormones were measured by the ELISA test, and the results were evaluated via the t-test, ANOVA, and Duncan. Results: The results showed a significant decrease in the concentrations of testosterone and progesterone (p value < 0.05) and a significant increase in the concentrations of LH and FSH (p value <0.05). Conclusion: Camphor augmented oogenesis via effecting a rise in the concentrations of LH and FSH in our rats. |
topic |
Camphor Oogenesis LH FSH Testosterone Rat |
url |
http://journal.fums.ac.ir/browse.php?a_code=A-10-26-33&slc_lang=en&sid=1 |
work_keys_str_mv |
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