Effect of Camphor on Pituitary-Gonadal Hormonal Axis and Oogenesis in Adult Female Rats

Background & Objective: Camphor stimulates the nervous system and the circulatory system, reduces lactation, and prevents conception and embryo embedding. We investigated the effects of camphor on the pituitary-gonadal hormonal axis and concentration of steroidal hormones.   Materials & Meth...

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Main Authors: Habibollah Johari, Amir Ashkan Mahjoor, Siyamak Fallahi, Hossein Kargar Jahromi, Maryam Abedini, Mohammad Ali Poor Danesh, Zahra Zamani
Format: Article
Language:fas
Published: Fasa University of Medical Sciences 2013-06-01
Series:Journal of Fasa University of Medical Sciences
Subjects:
LH
FSH
Rat
Online Access:http://journal.fums.ac.ir/browse.php?a_code=A-10-26-33&slc_lang=en&sid=1
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spelling doaj-a4641644a5c64a1888a0ad3ea0c169942020-11-24T21:59:20ZfasFasa University of Medical SciencesJournal of Fasa University of Medical Sciences2228-51052228-73292013-06-01316974Effect of Camphor on Pituitary-Gonadal Hormonal Axis and Oogenesis in Adult Female RatsHabibollah JohariAmir Ashkan MahjoorSiyamak FallahiHossein Kargar JahromiMaryam AbediniMohammad Ali Poor DaneshZahra ZamaniBackground & Objective: Camphor stimulates the nervous system and the circulatory system, reduces lactation, and prevents conception and embryo embedding. We investigated the effects of camphor on the pituitary-gonadal hormonal axis and concentration of steroidal hormones.   Materials & Methods: The parameters investigated were concentrations of LH, FSH, estrogen, progesterone, and testosterone. Forty adult female rats at a mean weight of 180 ± 20 grams were divided into five groups. Camphor solution was prepared in olive oil at 25, 50, and 100 mg/kg doses, and 0.2 cc injections were done intraperitoneally every day for 2 weeks. The control group received no injection. The sham group received olive oil (as solvent of camphor) and treatment groups of 1, 2, and 3 received doses of 25, 50, and 100 mg/kg. The treatment groups were sacrificed one day after the last injection, and their hearts were dissected and blood samples were obtained. The concentrations of the hormones were measured by the ELISA test, and the results were evaluated via the t-test, ANOVA, and Duncan.   Results: The results showed a significant decrease in the concentrations of testosterone and progesterone (p value < 0.05) and a significant increase in the concentrations of LH and FSH (p value <0.05).   Conclusion: Camphor augmented oogenesis via effecting a rise in the concentrations of LH and FSH in our rats. http://journal.fums.ac.ir/browse.php?a_code=A-10-26-33&slc_lang=en&sid=1CamphorOogenesisLHFSHTestosteroneRat
collection DOAJ
language fas
format Article
sources DOAJ
author Habibollah Johari
Amir Ashkan Mahjoor
Siyamak Fallahi
Hossein Kargar Jahromi
Maryam Abedini
Mohammad Ali Poor Danesh
Zahra Zamani
spellingShingle Habibollah Johari
Amir Ashkan Mahjoor
Siyamak Fallahi
Hossein Kargar Jahromi
Maryam Abedini
Mohammad Ali Poor Danesh
Zahra Zamani
Effect of Camphor on Pituitary-Gonadal Hormonal Axis and Oogenesis in Adult Female Rats
Journal of Fasa University of Medical Sciences
Camphor
Oogenesis
LH
FSH
Testosterone
Rat
author_facet Habibollah Johari
Amir Ashkan Mahjoor
Siyamak Fallahi
Hossein Kargar Jahromi
Maryam Abedini
Mohammad Ali Poor Danesh
Zahra Zamani
author_sort Habibollah Johari
title Effect of Camphor on Pituitary-Gonadal Hormonal Axis and Oogenesis in Adult Female Rats
title_short Effect of Camphor on Pituitary-Gonadal Hormonal Axis and Oogenesis in Adult Female Rats
title_full Effect of Camphor on Pituitary-Gonadal Hormonal Axis and Oogenesis in Adult Female Rats
title_fullStr Effect of Camphor on Pituitary-Gonadal Hormonal Axis and Oogenesis in Adult Female Rats
title_full_unstemmed Effect of Camphor on Pituitary-Gonadal Hormonal Axis and Oogenesis in Adult Female Rats
title_sort effect of camphor on pituitary-gonadal hormonal axis and oogenesis in adult female rats
publisher Fasa University of Medical Sciences
series Journal of Fasa University of Medical Sciences
issn 2228-5105
2228-7329
publishDate 2013-06-01
description Background & Objective: Camphor stimulates the nervous system and the circulatory system, reduces lactation, and prevents conception and embryo embedding. We investigated the effects of camphor on the pituitary-gonadal hormonal axis and concentration of steroidal hormones.   Materials & Methods: The parameters investigated were concentrations of LH, FSH, estrogen, progesterone, and testosterone. Forty adult female rats at a mean weight of 180 ± 20 grams were divided into five groups. Camphor solution was prepared in olive oil at 25, 50, and 100 mg/kg doses, and 0.2 cc injections were done intraperitoneally every day for 2 weeks. The control group received no injection. The sham group received olive oil (as solvent of camphor) and treatment groups of 1, 2, and 3 received doses of 25, 50, and 100 mg/kg. The treatment groups were sacrificed one day after the last injection, and their hearts were dissected and blood samples were obtained. The concentrations of the hormones were measured by the ELISA test, and the results were evaluated via the t-test, ANOVA, and Duncan.   Results: The results showed a significant decrease in the concentrations of testosterone and progesterone (p value < 0.05) and a significant increase in the concentrations of LH and FSH (p value <0.05).   Conclusion: Camphor augmented oogenesis via effecting a rise in the concentrations of LH and FSH in our rats.
topic Camphor
Oogenesis
LH
FSH
Testosterone
Rat
url http://journal.fums.ac.ir/browse.php?a_code=A-10-26-33&slc_lang=en&sid=1
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