DNAzyme conjugated nanomaterials for biosensing applications
DNAzymes are a series of functional oligonucleotides obtained through in vitro selection and able to catalyze the reaction of substrates with the help of some special cofactors such as metal ions, L-histidine and hemin. Compared with naturally occurring bio-enzymes, DNAzymes are more stable and amen...
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doaj-a4655f5eae2f4a9e865820cd0612a6f02021-09-05T14:00:14ZengDe GruyterReviews in Analytical Chemistry0793-01352191-01892014-10-0133320121210.1515/revac-2014-0006DNAzyme conjugated nanomaterials for biosensing applicationsGong Liang0Lv Yi-Fan1Liang Hao2Huan Shuang-Yan3Zhang Xiao-Bing4Zhang Wei Jun5Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering and College of Biology, Hunan University Changsha 410082, P.R. ChinaMolecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering and College of Biology, Hunan University Changsha 410082, P.R. ChinaMolecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering and College of Biology, Hunan University Changsha 410082, P.R. ChinaMolecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering and College of Biology, Hunan University Changsha 410082, P.R. ChinaMolecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering and College of Biology, Hunan University Changsha 410082, P.R. ChinaDepartment of Life Science and Chemical Engineering, Hunan University of Science and Engineering, Yongzhou 425199, P.R. ChinaDNAzymes are a series of functional oligonucleotides obtained through in vitro selection and able to catalyze the reaction of substrates with the help of some special cofactors such as metal ions, L-histidine and hemin. Compared with naturally occurring bio-enzymes, DNAzymes are more stable and amenable to modification and preparation. Due to their outstanding properties, DNAzymes have been widely used in biological applications, such as target detection and signal amplification. Nanomaterials, with special characteristics including quantum size effect, high biocompatibility, large surface-to-volume ratio and overall structural robustness, exhibit important application prospects in nanotechnology. By combining with a variety of nanomaterials, DNAzyme achieves a lot of special applications in biochemistry. This review summarizes recent achievements in the field of DNAzyme-conjugated nanomaterials for biosensing applications. For a brief demonstration, nanomaterials including gold nanoparticles, carbon nanomaterials, magnetic nanoparticles and semiconductor quantum dots are taken as examples.https://doi.org/10.1515/revac-2014-0006biosensingdnazymenanomaterials |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gong Liang Lv Yi-Fan Liang Hao Huan Shuang-Yan Zhang Xiao-Bing Zhang Wei Jun |
spellingShingle |
Gong Liang Lv Yi-Fan Liang Hao Huan Shuang-Yan Zhang Xiao-Bing Zhang Wei Jun DNAzyme conjugated nanomaterials for biosensing applications Reviews in Analytical Chemistry biosensing dnazyme nanomaterials |
author_facet |
Gong Liang Lv Yi-Fan Liang Hao Huan Shuang-Yan Zhang Xiao-Bing Zhang Wei Jun |
author_sort |
Gong Liang |
title |
DNAzyme conjugated nanomaterials for biosensing applications |
title_short |
DNAzyme conjugated nanomaterials for biosensing applications |
title_full |
DNAzyme conjugated nanomaterials for biosensing applications |
title_fullStr |
DNAzyme conjugated nanomaterials for biosensing applications |
title_full_unstemmed |
DNAzyme conjugated nanomaterials for biosensing applications |
title_sort |
dnazyme conjugated nanomaterials for biosensing applications |
publisher |
De Gruyter |
series |
Reviews in Analytical Chemistry |
issn |
0793-0135 2191-0189 |
publishDate |
2014-10-01 |
description |
DNAzymes are a series of functional oligonucleotides obtained through in vitro selection and able to catalyze the reaction of substrates with the help of some special cofactors such as metal ions, L-histidine and hemin. Compared with naturally occurring bio-enzymes, DNAzymes are more stable and amenable to modification and preparation. Due to their outstanding properties, DNAzymes have been widely used in biological applications, such as target detection and signal amplification. Nanomaterials, with special characteristics including quantum size effect, high biocompatibility, large surface-to-volume ratio and overall structural robustness, exhibit important application prospects in nanotechnology. By combining with a variety of nanomaterials, DNAzyme achieves a lot of special applications in biochemistry. This review summarizes recent achievements in the field of DNAzyme-conjugated nanomaterials for biosensing applications. For a brief demonstration, nanomaterials including gold nanoparticles, carbon nanomaterials, magnetic nanoparticles and semiconductor quantum dots are taken as examples. |
topic |
biosensing dnazyme nanomaterials |
url |
https://doi.org/10.1515/revac-2014-0006 |
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