CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis

CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis

CXCL4 is an inflammatory chemokine signaling through CXCR3 receptor. Here the authors show a CXCR3-independent function of CXCL4: it forms liquid crystals with DNA, potentiating mammalian and bacterial DNA recognition by TLR9, thereby amplifying interferon-a production in systemic sclerosis.

Bibliographic Details
Main Authors: Roberto Lande, Ernest Y. Lee, Raffaella Palazzo, Barbara Marinari, Immacolata Pietraforte, Giancarlo Santiago Santos, Yves Mattenberger, Francesca Spadaro, Katia Stefanantoni, Nicoletta Iannace, Aleksandra Maria Dufour, Mario Falchi, Manuela Bianco, Elisabetta Botti, Luca Bianchi, Montserrat Alvarez, Valeria Riccieri, Marie-Elise Truchetet, Gerard C.L. Wong, Carlo Chizzolini, Loredana Frasca
Format: Article
Language:English
Published: Nature Publishing Group 2019-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09683-z
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spelling doaj-a467d41eb1b041d3bfc13521f62a91e82021-05-11T12:04:26ZengNature Publishing GroupNature Communications2041-17232019-05-0110111410.1038/s41467-019-09683-zCXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosisRoberto Lande0Ernest Y. Lee1Raffaella Palazzo2Barbara Marinari3Immacolata Pietraforte4Giancarlo Santiago Santos5Yves Mattenberger6Francesca Spadaro7Katia Stefanantoni8Nicoletta Iannace9Aleksandra Maria Dufour10Mario Falchi11Manuela Bianco12Elisabetta Botti13Luca Bianchi14Montserrat Alvarez15Valeria Riccieri16Marie-Elise Truchetet17Gerard C.L. Wong18Carlo Chizzolini19Loredana Frasca20National Center for Drug Research and Evaluation, Pharmacological research and experimental therapy UNIT, Istituto Superiore di Sanità (ISS)Department of Bioengineering, Department of Chemistry & Biochemistry, and California NanoSystems Institute, University of CaliforniaNational Center for Drug Research and Evaluation, Pharmacological research and experimental therapy UNIT, Istituto Superiore di Sanità (ISS)Dermatology Unit, Department of Systems Medicine, University of Tor VergataDepartment of Oncology and Molecular Medicine, Istituto Superiore di SanitàDepartment of Bioengineering, Department of Chemistry & Biochemistry, and California NanoSystems Institute, University of CaliforniaDepartment of Microbiol and Molecular Medicine, University of GenevaIstituto Superiore di Sanità, Confocal Microscopy Unit, Core FacilitiesDivision of Rheumatology, Internal Medicine and Medical Specialties, University La SapienzaDivision of Rheumatology, Internal Medicine and Medical Specialties, University La SapienzaImmunology & Allergy and Immunology & Pathology, University Hospital and School of MedicineIstituto Superiore di Sanità, National AIDS CenterNational Center for Drug Research and Evaluation, Pharmacological research and experimental therapy UNIT, Istituto Superiore di Sanità (ISS)Dermatology Unit, Department of Systems Medicine, University of Tor VergataDermatology Unit, Department of Systems Medicine, University of Tor VergataImmunology & Allergy and Immunology & Pathology, University Hospital and School of MedicineDivision of Rheumatology, Internal Medicine and Medical Specialties, University La SapienzaDivision of Rheumatology and immunoConcept, University HospitalDepartment of Bioengineering, Department of Chemistry & Biochemistry, and California NanoSystems Institute, University of CaliforniaImmunology & Allergy and Immunology & Pathology, University Hospital and School of MedicineNational Center for Drug Research and Evaluation, Pharmacological research and experimental therapy UNIT, Istituto Superiore di Sanità (ISS)CXCL4 is an inflammatory chemokine signaling through CXCR3 receptor. Here the authors show a CXCR3-independent function of CXCL4: it forms liquid crystals with DNA, potentiating mammalian and bacterial DNA recognition by TLR9, thereby amplifying interferon-a production in systemic sclerosis.https://doi.org/10.1038/s41467-019-09683-z
collection DOAJ
language English
format Article
sources DOAJ
author Roberto Lande
Ernest Y. Lee
Raffaella Palazzo
Barbara Marinari
Immacolata Pietraforte
Giancarlo Santiago Santos
Yves Mattenberger
Francesca Spadaro
Katia Stefanantoni
Nicoletta Iannace
Aleksandra Maria Dufour
Mario Falchi
Manuela Bianco
Elisabetta Botti
Luca Bianchi
Montserrat Alvarez
Valeria Riccieri
Marie-Elise Truchetet
Gerard C.L. Wong
Carlo Chizzolini
Loredana Frasca
spellingShingle Roberto Lande
Ernest Y. Lee
Raffaella Palazzo
Barbara Marinari
Immacolata Pietraforte
Giancarlo Santiago Santos
Yves Mattenberger
Francesca Spadaro
Katia Stefanantoni
Nicoletta Iannace
Aleksandra Maria Dufour
Mario Falchi
Manuela Bianco
Elisabetta Botti
Luca Bianchi
Montserrat Alvarez
Valeria Riccieri
Marie-Elise Truchetet
Gerard C.L. Wong
Carlo Chizzolini
Loredana Frasca
CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis
Nature Communications
author_facet Roberto Lande
Ernest Y. Lee
Raffaella Palazzo
Barbara Marinari
Immacolata Pietraforte
Giancarlo Santiago Santos
Yves Mattenberger
Francesca Spadaro
Katia Stefanantoni
Nicoletta Iannace
Aleksandra Maria Dufour
Mario Falchi
Manuela Bianco
Elisabetta Botti
Luca Bianchi
Montserrat Alvarez
Valeria Riccieri
Marie-Elise Truchetet
Gerard C.L. Wong
Carlo Chizzolini
Loredana Frasca
author_sort Roberto Lande
title CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis
title_short CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis
title_full CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis
title_fullStr CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis
title_full_unstemmed CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis
title_sort cxcl4 assembles dna into liquid crystalline complexes to amplify tlr9-mediated interferon-α production in systemic sclerosis
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-05-01
description CXCL4 is an inflammatory chemokine signaling through CXCR3 receptor. Here the authors show a CXCR3-independent function of CXCL4: it forms liquid crystals with DNA, potentiating mammalian and bacterial DNA recognition by TLR9, thereby amplifying interferon-a production in systemic sclerosis.
url https://doi.org/10.1038/s41467-019-09683-z
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