Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies

Somatic mutations within antibody framework regions (FWR) can alter structural flexibility, but their role in maturation of broadly neutralizing antibodies (bnAbs) is unclear. Here the authors show how FWR mutations impact interdomain conformational flexibility and paratope plasticity during bnAb de...

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Main Authors:	Rory Henderson, Brian E. Watts, Hieu N. Ergin, Kara Anasti, Robert Parks, Shi-Mao Xia, Ashley Trama, Hua-Xin Liao, Kevin O. Saunders, Mattia Bonsignori, Kevin Wiehe, Barton F. Haynes, S. Munir Alam
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-08415-7

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spelling	doaj-a47579b2b60d4216bca8f50e6239686f2021-05-11T11:52:10ZengNature Publishing GroupNature Communications2041-17232019-02-0110111410.1038/s41467-019-08415-7Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodiesRory Henderson0Brian E. Watts1Hieu N. Ergin2Kara Anasti3Robert Parks4Shi-Mao Xia5Ashley Trama6Hua-Xin Liao7Kevin O. Saunders8Mattia Bonsignori9Kevin Wiehe10Barton F. Haynes11S. Munir Alam12Department of Medicine, Duke University School of MedicineDepartment of Medicine, Duke University School of MedicineDepartment of Medicine, Duke University School of MedicineDepartment of Medicine, Duke University School of MedicineDepartment of Medicine, Duke University School of MedicineDepartment of Medicine, Duke University School of MedicineDepartment of Medicine, Duke University School of MedicineDepartment of Medicine, Duke University School of MedicineDepartment of Medicine, Duke University School of MedicineDepartment of Medicine, Duke University School of MedicineDepartment of Medicine, Duke University School of MedicineDepartment of Medicine, Duke University School of MedicineDepartment of Medicine, Duke University School of MedicineSomatic mutations within antibody framework regions (FWR) can alter structural flexibility, but their role in maturation of broadly neutralizing antibodies (bnAbs) is unclear. Here the authors show how FWR mutations impact interdomain conformational flexibility and paratope plasticity during bnAb development.https://doi.org/10.1038/s41467-019-08415-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Rory Henderson Brian E. Watts Hieu N. Ergin Kara Anasti Robert Parks Shi-Mao Xia Ashley Trama Hua-Xin Liao Kevin O. Saunders Mattia Bonsignori Kevin Wiehe Barton F. Haynes S. Munir Alam
spellingShingle	Rory Henderson Brian E. Watts Hieu N. Ergin Kara Anasti Robert Parks Shi-Mao Xia Ashley Trama Hua-Xin Liao Kevin O. Saunders Mattia Bonsignori Kevin Wiehe Barton F. Haynes S. Munir Alam Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies Nature Communications
author_facet	Rory Henderson Brian E. Watts Hieu N. Ergin Kara Anasti Robert Parks Shi-Mao Xia Ashley Trama Hua-Xin Liao Kevin O. Saunders Mattia Bonsignori Kevin Wiehe Barton F. Haynes S. Munir Alam
author_sort	Rory Henderson
title	Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies
title_short	Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies
title_full	Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies
title_fullStr	Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies
title_full_unstemmed	Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies
title_sort	selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in hiv-1 broadly neutralizing antibodies
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-02-01
description	Somatic mutations within antibody framework regions (FWR) can alter structural flexibility, but their role in maturation of broadly neutralizing antibodies (bnAbs) is unclear. Here the authors show how FWR mutations impact interdomain conformational flexibility and paratope plasticity during bnAb development.
url	https://doi.org/10.1038/s41467-019-08415-7
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Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies

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