Does Coenzyme Q10 Supplementation Improve Testicular Function and Spermatogenesis in Male Mice with Chronic Kidney Disease?
The aim of the study was to examine the potential effects of coenzyme Q10 (CoQ10) on reproductive function in a chronic kidney disease (CKD) mouse model. Nine-week-old mice were randomly assigned to two groups: sham surgery (<i>n</i> = 18) and CKD surgery (<i>n</i> = 18). Aft...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-08-01
|
Series: | Biology |
Subjects: | |
Online Access: | https://www.mdpi.com/2079-7737/10/8/786 |
id |
doaj-a486a01cf55c4eb48531c7553b2ceef0 |
---|---|
record_format |
Article |
spelling |
doaj-a486a01cf55c4eb48531c7553b2ceef02021-08-26T13:32:19ZengMDPI AGBiology2079-77372021-08-011078678610.3390/biology10080786Does Coenzyme Q10 Supplementation Improve Testicular Function and Spermatogenesis in Male Mice with Chronic Kidney Disease?Chih-Wei Tsao0Yu-Juei Hsu1Xiang-Ting Tseng2Ting-Chia Chang3Chang-Huei Tsao4Chin-Yu Liu5Division of Urology, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, TaiwanDivision of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, TaiwanDepartment of Nutritional Science, Fu Jen Catholic University, New Taipei City 242062, TaiwanDepartment of Nutritional Science, Fu Jen Catholic University, New Taipei City 242062, TaiwanDepartment of Microbiology and Immunology, National Defense Medical Centre, Taipei 11490, TaiwanDepartment of Nutritional Science, Fu Jen Catholic University, New Taipei City 242062, TaiwanThe aim of the study was to examine the potential effects of coenzyme Q10 (CoQ10) on reproductive function in a chronic kidney disease (CKD) mouse model. Nine-week-old mice were randomly assigned to two groups: sham surgery (<i>n</i> = 18) and CKD surgery (<i>n</i> = 18). After surgery, the study groups received CoQ10 (10 mg/kg body weight dissolved in corn oil by oral gavage) or corn oil as a vehicle daily for 8 weeks. The groups that underwent 5/6 nephrectomy developed significant elevations of serum BUN and creatinine levels. The CoQ10 treatment significantly increased the serum and testicular CoQ10 levels and alleviated the poor semen quality from incomplete spermatogenesis. The testosterone concentration, in addition to the protein expression of enzymes related to testosterone biosynthesis, was also elevated, and the CKD-induced decrease in antioxidant activity in the testes was significantly ameliorated. The results suggest that CoQ10 could act against CKD-induced testicular dysfunction through improvements in the sperm function, testicular morphology, testosterone levels and related biosynthesis pathways, in addition to antioxidant activity.https://www.mdpi.com/2079-7737/10/8/786coenzyme Q10chronic kidney diseasespermatogenesisoxidative stressmitochondria |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chih-Wei Tsao Yu-Juei Hsu Xiang-Ting Tseng Ting-Chia Chang Chang-Huei Tsao Chin-Yu Liu |
spellingShingle |
Chih-Wei Tsao Yu-Juei Hsu Xiang-Ting Tseng Ting-Chia Chang Chang-Huei Tsao Chin-Yu Liu Does Coenzyme Q10 Supplementation Improve Testicular Function and Spermatogenesis in Male Mice with Chronic Kidney Disease? Biology coenzyme Q10 chronic kidney disease spermatogenesis oxidative stress mitochondria |
author_facet |
Chih-Wei Tsao Yu-Juei Hsu Xiang-Ting Tseng Ting-Chia Chang Chang-Huei Tsao Chin-Yu Liu |
author_sort |
Chih-Wei Tsao |
title |
Does Coenzyme Q10 Supplementation Improve Testicular Function and Spermatogenesis in Male Mice with Chronic Kidney Disease? |
title_short |
Does Coenzyme Q10 Supplementation Improve Testicular Function and Spermatogenesis in Male Mice with Chronic Kidney Disease? |
title_full |
Does Coenzyme Q10 Supplementation Improve Testicular Function and Spermatogenesis in Male Mice with Chronic Kidney Disease? |
title_fullStr |
Does Coenzyme Q10 Supplementation Improve Testicular Function and Spermatogenesis in Male Mice with Chronic Kidney Disease? |
title_full_unstemmed |
Does Coenzyme Q10 Supplementation Improve Testicular Function and Spermatogenesis in Male Mice with Chronic Kidney Disease? |
title_sort |
does coenzyme q10 supplementation improve testicular function and spermatogenesis in male mice with chronic kidney disease? |
publisher |
MDPI AG |
series |
Biology |
issn |
2079-7737 |
publishDate |
2021-08-01 |
description |
The aim of the study was to examine the potential effects of coenzyme Q10 (CoQ10) on reproductive function in a chronic kidney disease (CKD) mouse model. Nine-week-old mice were randomly assigned to two groups: sham surgery (<i>n</i> = 18) and CKD surgery (<i>n</i> = 18). After surgery, the study groups received CoQ10 (10 mg/kg body weight dissolved in corn oil by oral gavage) or corn oil as a vehicle daily for 8 weeks. The groups that underwent 5/6 nephrectomy developed significant elevations of serum BUN and creatinine levels. The CoQ10 treatment significantly increased the serum and testicular CoQ10 levels and alleviated the poor semen quality from incomplete spermatogenesis. The testosterone concentration, in addition to the protein expression of enzymes related to testosterone biosynthesis, was also elevated, and the CKD-induced decrease in antioxidant activity in the testes was significantly ameliorated. The results suggest that CoQ10 could act against CKD-induced testicular dysfunction through improvements in the sperm function, testicular morphology, testosterone levels and related biosynthesis pathways, in addition to antioxidant activity. |
topic |
coenzyme Q10 chronic kidney disease spermatogenesis oxidative stress mitochondria |
url |
https://www.mdpi.com/2079-7737/10/8/786 |
work_keys_str_mv |
AT chihweitsao doescoenzymeq10supplementationimprovetesticularfunctionandspermatogenesisinmalemicewithchronickidneydisease AT yujueihsu doescoenzymeq10supplementationimprovetesticularfunctionandspermatogenesisinmalemicewithchronickidneydisease AT xiangtingtseng doescoenzymeq10supplementationimprovetesticularfunctionandspermatogenesisinmalemicewithchronickidneydisease AT tingchiachang doescoenzymeq10supplementationimprovetesticularfunctionandspermatogenesisinmalemicewithchronickidneydisease AT changhueitsao doescoenzymeq10supplementationimprovetesticularfunctionandspermatogenesisinmalemicewithchronickidneydisease AT chinyuliu doescoenzymeq10supplementationimprovetesticularfunctionandspermatogenesisinmalemicewithchronickidneydisease |
_version_ |
1721194844017131520 |