Relationship Between the Free and Total Methotrexate Plasma Concentration in Children and Application to Predict the Toxicity of HD-MTX

Relationship Between the Free and Total Methotrexate Plasma Concentration in Children and Application to Predict the Toxicity of HD-MTX

High-dose methotrexate (HD-MTX) can be highly effective as well as extremely toxic. Many drug molecules can bind to plasma proteins to different extents in vivo, whereas only the free drug can reach the site of action to exert a pharmacological effect and cause toxicity. However, free MTX concentrat...

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Bibliographic Details
Main Authors: Wei-Chong Dong, Jia-Liang Guo, Xi-Kun Wu, Meng-Qiang Zhao, Hao-Ran Li, Zhi-Qing Zhang, Ye Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
methotrexate
free concentration
total concentration
HFCF-UF
nephrotoxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.636975/full

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