Association of alpha1a-adrenergic receptor polymorphism and blood pressure phenotypes in the Brazilian population

<p>Abstract</p> <p>Background</p> <p>The alpha1A-adrenergic receptor (α<sub>1A</sub>-AR) regulates the cardiac and peripheral vascular system through sympathetic activation. Due to its important role in the regulation of vascular tone and blood pressure, we...

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Main Authors: Mill José G, Floriano Marcilene S, Pereira Alexandre C, Freitas Silvia R, Krieger José E
Format: Article
Language:English
Published: BMC 2008-12-01
Series:BMC Cardiovascular Disorders
Online Access:http://www.biomedcentral.com/1471-2261/8/40
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spelling doaj-a49282392e9c4e40a70acabd56f15e202020-11-25T03:42:09ZengBMCBMC Cardiovascular Disorders1471-22612008-12-01814010.1186/1471-2261-8-40Association of alpha1a-adrenergic receptor polymorphism and blood pressure phenotypes in the Brazilian populationMill José GFloriano Marcilene SPereira Alexandre CFreitas Silvia RKrieger José E<p>Abstract</p> <p>Background</p> <p>The alpha1A-adrenergic receptor (α<sub>1A</sub>-AR) regulates the cardiac and peripheral vascular system through sympathetic activation. Due to its important role in the regulation of vascular tone and blood pressure, we aimed to investigate the association between the Arg347Cys polymorphism in the α<sub>1A</sub>-AR gene and blood pressure phenotypes, in a large sample of Brazilians from an urban population.</p> <p>Methods</p> <p>A total of 1568 individuals were randomly selected from the general population of the Vitória City metropolitan area. Genetic analysis of the Arg347Cys polymorphism was conducted by polymerase chain reaction/restriction fragment length polymorphism. We have compared cardiovascular risk variables and genotypes using ANOVA, and Chi-square test for univariate comparisons and logistic regression for multivariate comparisons.</p> <p>Results</p> <p>Association analysis indicated a significant difference between genotype groups with respect to diastolic blood pressure (p = 0.04), but not systolic blood pressure (p = 0.12). In addition, presence of the Cys/Cys genotype was marginally associated with hypertension in our population (p = 0.06). Significant interaction effects were observed between the studied genetic variant, age and physical activity. Presence of the Cys/Cys genotype was associated with hypertension only in individuals with regular physical activity (odds ratio = 1.86; p = 0.03) or younger than 45 years (odds ratio = 1.27; p = 0.04).</p> <p>Conclusion</p> <p>Physical activity and age may potentially play a role by disclosing the effects of the Cys allele on blood pressure. According to our data it is possible that the Arg347Cys polymorphism can be used as a biomarker to disease risk in a selected group of individuals.</p> http://www.biomedcentral.com/1471-2261/8/40
collection DOAJ
language English
format Article
sources DOAJ
author Mill José G
Floriano Marcilene S
Pereira Alexandre C
Freitas Silvia R
Krieger José E
spellingShingle Mill José G
Floriano Marcilene S
Pereira Alexandre C
Freitas Silvia R
Krieger José E
Association of alpha1a-adrenergic receptor polymorphism and blood pressure phenotypes in the Brazilian population
BMC Cardiovascular Disorders
author_facet Mill José G
Floriano Marcilene S
Pereira Alexandre C
Freitas Silvia R
Krieger José E
author_sort Mill José G
title Association of alpha1a-adrenergic receptor polymorphism and blood pressure phenotypes in the Brazilian population
title_short Association of alpha1a-adrenergic receptor polymorphism and blood pressure phenotypes in the Brazilian population
title_full Association of alpha1a-adrenergic receptor polymorphism and blood pressure phenotypes in the Brazilian population
title_fullStr Association of alpha1a-adrenergic receptor polymorphism and blood pressure phenotypes in the Brazilian population
title_full_unstemmed Association of alpha1a-adrenergic receptor polymorphism and blood pressure phenotypes in the Brazilian population
title_sort association of alpha1a-adrenergic receptor polymorphism and blood pressure phenotypes in the brazilian population
publisher BMC
series BMC Cardiovascular Disorders
issn 1471-2261
publishDate 2008-12-01
description <p>Abstract</p> <p>Background</p> <p>The alpha1A-adrenergic receptor (α<sub>1A</sub>-AR) regulates the cardiac and peripheral vascular system through sympathetic activation. Due to its important role in the regulation of vascular tone and blood pressure, we aimed to investigate the association between the Arg347Cys polymorphism in the α<sub>1A</sub>-AR gene and blood pressure phenotypes, in a large sample of Brazilians from an urban population.</p> <p>Methods</p> <p>A total of 1568 individuals were randomly selected from the general population of the Vitória City metropolitan area. Genetic analysis of the Arg347Cys polymorphism was conducted by polymerase chain reaction/restriction fragment length polymorphism. We have compared cardiovascular risk variables and genotypes using ANOVA, and Chi-square test for univariate comparisons and logistic regression for multivariate comparisons.</p> <p>Results</p> <p>Association analysis indicated a significant difference between genotype groups with respect to diastolic blood pressure (p = 0.04), but not systolic blood pressure (p = 0.12). In addition, presence of the Cys/Cys genotype was marginally associated with hypertension in our population (p = 0.06). Significant interaction effects were observed between the studied genetic variant, age and physical activity. Presence of the Cys/Cys genotype was associated with hypertension only in individuals with regular physical activity (odds ratio = 1.86; p = 0.03) or younger than 45 years (odds ratio = 1.27; p = 0.04).</p> <p>Conclusion</p> <p>Physical activity and age may potentially play a role by disclosing the effects of the Cys allele on blood pressure. According to our data it is possible that the Arg347Cys polymorphism can be used as a biomarker to disease risk in a selected group of individuals.</p>
url http://www.biomedcentral.com/1471-2261/8/40
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