Expression of Human ACE2 N-terminal Domain, Part of the Receptor for SARS-CoV-2, in Fusion With Maltose-Binding Protein, E. coli Ribonuclease I and Human RNase A
The SARS-CoV-2 viral genome contains a positive-strand single-stranded RNA of ∼30 kb. Human ACE2 protein is the receptor for SARS-CoV-2 virus attachment and infection. We propose to use ribonucleases (RNases) as antiviral agents to destroy the viral genome in vitro. In the virions, the RNA is protec...
Main Authors: | Shuang-yong Xu, Alexey Fomenkov, Tien-Hao Chen, Erbay Yigit |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-06-01
|
Series: | Frontiers in Microbiology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2021.660149/full |
Similar Items
-
The Ribonuclease A Superfamily in Humans: Canonical RNases as the Buttress of Innate Immunity
by: Patrick Koczera, et al.
Published: (2016-08-01) -
Funktion und Zusammensetzung der nukleären
RNase P und RNase MRP in Pflanzen
by: Krehan, Mario
Published: (2012) -
Exoribonucleases as modulators of virulence in pathogenic bacteria
by: Rute G. Matos, et al.
Published: (2012-05-01) -
Editorial: Role of Ribonucleases in Immune Response Regulation During Infection and Cancer
by: Ester Boix, et al.
Published: (2020-02-01) -
Engineering and production of recombinant bovine pancreatic ribonuclease enzyme (RNase A) as a potential therapeutic
by: Masoume Vakili-Azghandi, et al.
Published: (2021-01-01)