Indirubin-3′-monoxime suppresses amyloid-beta- induced apoptosis by inhibiting tau hyperphosphorylation
Indirubin-3′-monoxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer′s disease. Here, we found that indirubin-3′-monoxime improved the morphology and increased the survival rate of SH-SY5Y cells exposed to amyloid-beta...
Main Authors: | Shu-gang Zhang, Xiao-shan Wang, Ying-dong Zhang, Qing Di, Jing-ping Shi, Min Qian, Li-gang Xu, Xing-jian Lin, Jie Lu |
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Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2016-01-01
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Series: | Neural Regeneration Research |
Subjects: | |
Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=6;spage=988;epage=993;aulast=Zhang |
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