Constituent ratio and changing trend of non-infectious liver diseases in The Fifth Medical Center of Chinese PLA General Hospital from 2002 to 2018

• Main Author: HE Tingting
• Format: Article
• Language: zho
• Published: Editorial Department of Journal of Clinical Hepatology 2020-08-01
• Series: Linchuang Gandanbing Zazhi
• Online Access: http://www.lcgdbzz.org/qk_content.asp?id=10962
• ISSN: 1001-5256; 1001-5256

ObjectiveTo investigate the constituent ratio and changing trend of four common types of non-infectious liver diseases in our hospital from 2002 to 2018. MethodsMedical records were collected from 37 973 patients with non-infectious liver diseases who were admitted to The Fifth Medical Center of Chinese PLA General Hospital from 2002 to 2018, and according to the first diagnosis listed in the first page of discharge medical records, 14 971 patients had alcoholic liver disease, 11 406 had drug-induced liver injury, 1776 had nonalcoholic fatty liver disease, and 9820 had autoimmune liver diseases. The distribution characteristics of age and sex and the changing trend were analyzed. The chi-square test was used for comparison of categorical data between groups. ResultsThe patients with drug-induced liver injury accounted for 30.04% of the patients with common non-infectious liver diseases, and it ranked only second to alcoholic liver diseases in all four types. The proportion of patients with drug-induced liver injury among the hospitalized patients with liver diseases tended to increase before 2011, and this constituent ratio showed a trend of transient reduction after 2012. There was a significant difference in sex distribution between the patients with different ages (χ2=113.087, P＜0.05). The age of onset was mainly 40-49 years in male patients and 50-59 years in female patients. There were significant differences in the age distribution of drug-induced liver injury between the male and female patients hospitalized in different years (χ2=369.252 and 663.490, both P＜0.05). There was no significant change in the range of peak age of onset in male patients, while in female patients, the range of peak age of onset showed an aging trend from 40-49 years to 50-59 years in the recent 6 years. ConclusionDrug-induced liver injury has become a major part of non-infectious liver disease and often occurs in middle-aged and elderly women. The prevention, control, diagnosis, and treatment of drug-induced liver injury should be taken seriously, especially medication guide and education for middle-aged and elderly women, and it is recommended to strengthen the monitoring of liver function during medication.