MEDICINAL FORM OF TNF-α FOR LOCAL ADMINISTRATION

MEDICINAL FORM OF TNF-α FOR LOCAL ADMINISTRATION

Composite preparation of tumor necrosis factor alpha and rheopolyglukin and polyethylene glycol (TNF-α+PG+PEG) was obtained. The specific activity of the samples was 4,13 х 107 IU/mg. The cytolytic activity of drugs TNF-α+PG+PEG and rhTNF-α did not change after 4 months when stored at 6 °С. Preparat...

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Bibliographic Details
Main Authors: S. G. Gamaley, A. V. Bateneva, Z. F. Urmantseva, G. M. Sisoyeva, Ya. V. Markus, E. D. Danilenko, V. K. Mikhaylova, E. A. Volosnikova, G. M. Levagina, V. I. Masicheva
Format: Article
Language:Russian
Published: Scientific Сentre for Family Health and Human Reproduction Problems 2012-05-01
Series:Acta Biomedica Scientifica
Subjects:
tumor necrosis factor alpha
tnf-α
rheopolyglukin
polyethylene glycol
Online Access:https://www.actabiomedica.ru/jour/article/view/931
Description
Summary:Composite preparation of tumor necrosis factor alpha and rheopolyglukin and polyethylene glycol (TNF-α+PG+PEG) was obtained. The specific activity of the samples was 4,13 х 107 IU/mg. The cytolytic activity of drugs TNF-α+PG+PEG and rhTNF-α did not change after 4 months when stored at 6 °С. Preparation TNF-α+PG+PEG provided a moderately prolonged elevation of TNF-alpha in blood of laboratory mice in contrast to TNF-α when they applied to the skin. The composite preparation did not have toxic, allergic and locally irritating action in experiments on laboratory animals.
ISSN:2541-9420
2587-9596

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