Predicting alcohol use disorder remission: a longitudinal multimodal multi-featured machine learning approach

• Main Authors: Sivan Kinreich, Vivia V. McCutcheon, Fazil Aliev, Jacquelyn L. Meyers, Chella Kamarajan, Ashwini K. Pandey, David B. Chorlian, Jian Zhang, Weipeng Kuang, Gayathri Pandey, Stacey Subbie-Saenz de. Viteri, Meredith W. Francis, Grace Chan, Jessica L. Bourdon, Danielle M. Dick, Andrey P. Anokhin, Lance Bauer, Victor Hesselbrock, Marc A. Schuckit, John I. Nurnberger, Tatiana M. Foroud, Jessica E. Salvatore, Kathleen K. Bucholz, Bernice Porjesz
• Format: Article
• Language: English
• Published: Nature Publishing Group 2021-03-01
• Series: Translational Psychiatry
• Online Access: https://doi.org/10.1038/s41398-021-01281-2

Abstract Predictive models for recovering from alcohol use disorder (AUD) and identifying related predisposition biomarkers can have a tremendous impact on addiction treatment outcomes and cost reduction. Our sample (N = 1376) included individuals of European (EA) and African (AA) ancestry from the Collaborative Study on the Genetics of Alcoholism (COGA) who were initially assessed as having AUD (DSM-5) and reassessed years later as either having AUD or in remission. To predict this difference in AUD recovery status, we analyzed the initial data using multimodal, multi-features machine learning applications including EEG source-level functional brain connectivity, Polygenic Risk Scores (PRS), medications, and demographic information. Sex and ancestry age-matched stratified analyses were performed with supervised linear Support Vector Machine application and were calculated twice, once when the ancestry was defined by self-report and once defined by genetic data. Multifeatured prediction models achieved higher accuracy scores than models based on a single domain and higher scores in male models when the ancestry was based on genetic data. The AA male group model with PRS, EEG functional connectivity, marital and employment status features achieved the highest accuracy of 86.04%. Several discriminative features were identified, including collections of PRS related to neuroticism, depression, aggression, years of education, and alcohol consumption phenotypes. Other discriminated features included being married, employed, medication, lower default mode network and fusiform connectivity, and higher insula connectivity. Results highlight the importance of increasing genetic homogeneity of analyzed groups, identifying sex, and ancestry-specific features to increase prediction scores revealing biomarkers related to AUD remission.