Brain stem adenosine receptors modulate centrally mediated hypotensive responses in conscious rats: A review
Adenosine is implicated in the modulation of cardiovascular responses either at the peripheral or at central level in experimental animals. However, there are no dedicated reviews on the involvement of adenosine in mediating the hypotensive response of centrally administered clonidine in general and...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2015-05-01
|
Series: | Journal of Advanced Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2090123214001520 |
id |
doaj-a4bb7125e67b4bffa45d12dafd070165 |
---|---|
record_format |
Article |
spelling |
doaj-a4bb7125e67b4bffa45d12dafd0701652020-11-24T23:21:58ZengElsevierJournal of Advanced Research2090-12322090-12242015-05-016333134010.1016/j.jare.2014.12.005Brain stem adenosine receptors modulate centrally mediated hypotensive responses in conscious rats: A reviewNoha N. Nassar0Abdel A. Abdel-Rahman1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, EgyptDepartment of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, NC, USAAdenosine is implicated in the modulation of cardiovascular responses either at the peripheral or at central level in experimental animals. However, there are no dedicated reviews on the involvement of adenosine in mediating the hypotensive response of centrally administered clonidine in general and specifically in aortically barodenervated rats (ABD). The conscious ABD rat model exhibits surgically induced baroreflex dysfunction and exaggerated hypotensive response, compared with conscious sham-operated (SO) rats. The current review focuses on, the role of adenosine receptors in blood pressure (BP) regulation and their possible crosstalk with other receptors e.g. imidazoline (I1) and alpha (α2A) adrenergic receptor (AR). The former receptor is a molecular target for clonidine, whose hypotensive effect is enhanced approx. 3-fold in conscious ABD rats. We also discussed how the balance between the brain stem adenosine A1 and A2A receptors is regulated by baroreceptors and how such balance influences the centrally mediated hypotensive responses. The use of the ABD rat model yielded insight into the downstream signaling cascades following clonidine-evoked hypotension in a surgical model of baroreflex dysfunction.http://www.sciencedirect.com/science/article/pii/S2090123214001520Imidazoline I1-receptorCentrally mediated hypotensionClonidineCentral adenosine receptorsConscious ratsMAPK-NOS signaling |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Noha N. Nassar Abdel A. Abdel-Rahman |
spellingShingle |
Noha N. Nassar Abdel A. Abdel-Rahman Brain stem adenosine receptors modulate centrally mediated hypotensive responses in conscious rats: A review Journal of Advanced Research Imidazoline I1-receptor Centrally mediated hypotension Clonidine Central adenosine receptors Conscious rats MAPK-NOS signaling |
author_facet |
Noha N. Nassar Abdel A. Abdel-Rahman |
author_sort |
Noha N. Nassar |
title |
Brain stem adenosine receptors modulate centrally mediated hypotensive responses in conscious rats: A review |
title_short |
Brain stem adenosine receptors modulate centrally mediated hypotensive responses in conscious rats: A review |
title_full |
Brain stem adenosine receptors modulate centrally mediated hypotensive responses in conscious rats: A review |
title_fullStr |
Brain stem adenosine receptors modulate centrally mediated hypotensive responses in conscious rats: A review |
title_full_unstemmed |
Brain stem adenosine receptors modulate centrally mediated hypotensive responses in conscious rats: A review |
title_sort |
brain stem adenosine receptors modulate centrally mediated hypotensive responses in conscious rats: a review |
publisher |
Elsevier |
series |
Journal of Advanced Research |
issn |
2090-1232 2090-1224 |
publishDate |
2015-05-01 |
description |
Adenosine is implicated in the modulation of cardiovascular responses either at the peripheral or at central level in experimental animals. However, there are no dedicated reviews on the involvement of adenosine in mediating the hypotensive response of centrally administered clonidine in general and specifically in aortically barodenervated rats (ABD). The conscious ABD rat model exhibits surgically induced baroreflex dysfunction and exaggerated hypotensive response, compared with conscious sham-operated (SO) rats. The current review focuses on, the role of adenosine receptors in blood pressure (BP) regulation and their possible crosstalk with other receptors e.g. imidazoline (I1) and alpha (α2A) adrenergic receptor (AR). The former receptor is a molecular target for clonidine, whose hypotensive effect is enhanced approx. 3-fold in conscious ABD rats. We also discussed how the balance between the brain stem adenosine A1 and A2A receptors is regulated by baroreceptors and how such balance influences the centrally mediated hypotensive responses. The use of the ABD rat model yielded insight into the downstream signaling cascades following clonidine-evoked hypotension in a surgical model of baroreflex dysfunction. |
topic |
Imidazoline I1-receptor Centrally mediated hypotension Clonidine Central adenosine receptors Conscious rats MAPK-NOS signaling |
url |
http://www.sciencedirect.com/science/article/pii/S2090123214001520 |
work_keys_str_mv |
AT nohannassar brainstemadenosinereceptorsmodulatecentrallymediatedhypotensiveresponsesinconsciousratsareview AT abdelaabdelrahman brainstemadenosinereceptorsmodulatecentrallymediatedhypotensiveresponsesinconsciousratsareview |
_version_ |
1725569140378304512 |