Progesterone Induces Mucosal Immunity in a Rodent Model of Human Taeniosis by Taenia solium
<p>More than one quarter of human world's population is exposed to intestinal helminth parasites. The <i>Taenia solium</i> tapeworm carrier is the main risk factor in the transmission of both human neurocysticercosis and porcine cysticercosis. Sex steroids play an important ro...
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doaj-a4bbd9f16c264f79a83975cb59ec457d2020-11-24T22:36:05ZengIvyspring International PublisherInternational Journal of Biological Sciences1449-22882011-01-017914431456Progesterone Induces Mucosal Immunity in a Rodent Model of Human Taeniosis by Taenia soliumGalileo Escobedo, Ignacio Camacho-Arroyo, Paul Nava-Luna, Alfonso Olivos, Armando Pérez-Torres, Sonia Leon-Cabrera, J.C. Carrero, Jorge Morales-Montor<p>More than one quarter of human world's population is exposed to intestinal helminth parasites. The <i>Taenia solium</i> tapeworm carrier is the main risk factor in the transmission of both human neurocysticercosis and porcine cysticercosis. Sex steroids play an important role during <i>T. solium</i> infection, particularly progesterone has been proposed as a key immunomodulatory hormone involved in susceptibility to human taeniosis in woman and cysticercosis in pregnant pigs. Thus, we evaluated the effect of progesterone administration upon the experimental taeniosis in golden hamsters (<i>Mesocricetus auratus</i>). Intact female adult hamsters were randomly divided into 3 groups: progesterone-subcutaneously treated; olive oil-treated as the vehicle group; and untreated controls. Animals were treated every other day during 4 weeks. After 2 weeks of treatment, all hamsters were orally infected with 4 viable <i>T. solium</i> cysticerci. After 2 weeks post infection, progesterone-treated hamsters showed reduction in adult worm recovery by 80%, compared to both vehicle-treated and non-manipulated infected animals. In contrast to control and vehicle groups, progesterone treatment diminished tapeworm length by 75% and increased proliferation rate of leukocytes from spleen and mesenteric lymph nodes of infected hamsters by 5-fold. The latter exhibited high expression levels of IL-4, IL-6 and TNF-α at the duodenal mucosa, accompanied with polymorphonuclear leukocytes infiltration. These results support that progesterone protects hamsters from the <i>T. solium</i> adult tapeworm establishment by improving the intestinal mucosal immunity, suggesting a potential use of analogues of this hormone as novel inductors of the gut immune response against intestinal helminth infections and probably other bowel-related disorders.</p>http://www.biolsci.org/v07p1443.htm |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Galileo Escobedo, Ignacio Camacho-Arroyo, Paul Nava-Luna, Alfonso Olivos, Armando Pérez-Torres, Sonia Leon-Cabrera, J.C. Carrero, Jorge Morales-Montor |
spellingShingle |
Galileo Escobedo, Ignacio Camacho-Arroyo, Paul Nava-Luna, Alfonso Olivos, Armando Pérez-Torres, Sonia Leon-Cabrera, J.C. Carrero, Jorge Morales-Montor Progesterone Induces Mucosal Immunity in a Rodent Model of Human Taeniosis by Taenia solium International Journal of Biological Sciences |
author_facet |
Galileo Escobedo, Ignacio Camacho-Arroyo, Paul Nava-Luna, Alfonso Olivos, Armando Pérez-Torres, Sonia Leon-Cabrera, J.C. Carrero, Jorge Morales-Montor |
author_sort |
Galileo Escobedo, Ignacio Camacho-Arroyo, Paul Nava-Luna, Alfonso Olivos, Armando Pérez-Torres, Sonia Leon-Cabrera, J.C. Carrero, Jorge Morales-Montor |
title |
Progesterone Induces Mucosal Immunity in a Rodent Model of Human Taeniosis by Taenia solium |
title_short |
Progesterone Induces Mucosal Immunity in a Rodent Model of Human Taeniosis by Taenia solium |
title_full |
Progesterone Induces Mucosal Immunity in a Rodent Model of Human Taeniosis by Taenia solium |
title_fullStr |
Progesterone Induces Mucosal Immunity in a Rodent Model of Human Taeniosis by Taenia solium |
title_full_unstemmed |
Progesterone Induces Mucosal Immunity in a Rodent Model of Human Taeniosis by Taenia solium |
title_sort |
progesterone induces mucosal immunity in a rodent model of human taeniosis by taenia solium |
publisher |
Ivyspring International Publisher |
series |
International Journal of Biological Sciences |
issn |
1449-2288 |
publishDate |
2011-01-01 |
description |
<p>More than one quarter of human world's population is exposed to intestinal helminth parasites. The <i>Taenia solium</i> tapeworm carrier is the main risk factor in the transmission of both human neurocysticercosis and porcine cysticercosis. Sex steroids play an important role during <i>T. solium</i> infection, particularly progesterone has been proposed as a key immunomodulatory hormone involved in susceptibility to human taeniosis in woman and cysticercosis in pregnant pigs. Thus, we evaluated the effect of progesterone administration upon the experimental taeniosis in golden hamsters (<i>Mesocricetus auratus</i>). Intact female adult hamsters were randomly divided into 3 groups: progesterone-subcutaneously treated; olive oil-treated as the vehicle group; and untreated controls. Animals were treated every other day during 4 weeks. After 2 weeks of treatment, all hamsters were orally infected with 4 viable <i>T. solium</i> cysticerci. After 2 weeks post infection, progesterone-treated hamsters showed reduction in adult worm recovery by 80%, compared to both vehicle-treated and non-manipulated infected animals. In contrast to control and vehicle groups, progesterone treatment diminished tapeworm length by 75% and increased proliferation rate of leukocytes from spleen and mesenteric lymph nodes of infected hamsters by 5-fold. The latter exhibited high expression levels of IL-4, IL-6 and TNF-α at the duodenal mucosa, accompanied with polymorphonuclear leukocytes infiltration. These results support that progesterone protects hamsters from the <i>T. solium</i> adult tapeworm establishment by improving the intestinal mucosal immunity, suggesting a potential use of analogues of this hormone as novel inductors of the gut immune response against intestinal helminth infections and probably other bowel-related disorders.</p> |
url |
http://www.biolsci.org/v07p1443.htm |
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