Different effects of paliperidone and risperidone therapy on blood lipid and Hcy metabolism as well as endocrine hormones in patients with schizophrenia

• Main Authors: Bei-Fang Fan, Ze-Hui Li, Shuo Yang, Cai-Hong Gao
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-11-01
• Series: Journal of Hainan Medical University
• Subjects: Schizophrenia; Paliperidone; Risperidone; Hcy; Endocrine hormone
• Online Access: http://www.hnykdxxb.com/PDF/201721/37.pdf

Objective: To explore the different effects of paliperidone and risperidone therapy on blood lipid and Hcy metabolism as well as endocrine hormones in patients with schizophrenia. Methods: A total of 118 patients with schizophrenia who were treated in the hospital between December 2014 and February 2017 were collected as the research subjects and divided into control group and study group by random number table, each group with 59 cases. Control group received risperidone therapy, observation group received paliperidone therapy, and the differences in the levels of blood lipid indexes, Hcy metabolism indexes and endocrine hormones were compared between the two groups before and after treatment. Results: There was no statistically significant difference in the levels of blood lipid indexes, Hcy and endocrine hormones between the two groups before treatment. After treatment, lipid indexes TG and TC levels in peripheral blood of study group were lower than those of control group while HDL-C content was higher than that of control group; Hcy level in serum of study group was lower than that of control group; endocrine hormones FT3, FT4, T and E2 levels in serum of study group were higher than those of control group. Conclusion: paliperidone therapy for schizophrenia can be more effective than risperidone in regulating blood lipid metabolism, Hcy metabolism and endocrine hormones.