Organoids as a Powerful Model for Respiratory Diseases
Insults to the alveoli usually lead to inefficient gas exchange or even respiratory failure, which is difficult to model in animal studies. Over the past decade, stem cell-derived self-organizing three-dimensional organoids have emerged as a new avenue to recapitulate respiratory diseases in a dish....
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Hindawi Limited
2020-01-01
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Series: | Stem Cells International |
Online Access: | http://dx.doi.org/10.1155/2020/5847876 |
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doaj-a4c6e91260af47518be2dad6bb81f7732020-11-25T02:59:32ZengHindawi LimitedStem Cells International1687-966X1687-96782020-01-01202010.1155/2020/58478765847876Organoids as a Powerful Model for Respiratory DiseasesYu Li0Qi Wu1Xin Sun2Jun Shen3Huaiyong Chen4Department of Basic Medicine, Tianjin University Haihe Hospital, Tianjin, ChinaKey Research Laboratory for Infectious Disease Prevention for State Administration of Traditional Chinese Medicine, Tianjin Institute of Respiratory Diseases, Tianjin, ChinaKey Research Laboratory for Infectious Disease Prevention for State Administration of Traditional Chinese Medicine, Tianjin Institute of Respiratory Diseases, Tianjin, ChinaDepartment of Basic Medicine, Tianjin University Haihe Hospital, Tianjin, ChinaDepartment of Basic Medicine, Tianjin University Haihe Hospital, Tianjin, ChinaInsults to the alveoli usually lead to inefficient gas exchange or even respiratory failure, which is difficult to model in animal studies. Over the past decade, stem cell-derived self-organizing three-dimensional organoids have emerged as a new avenue to recapitulate respiratory diseases in a dish. Alveolar organoids have improved our understanding of the mechanisms underlying tissue homeostasis and pathological alterations in alveoli. From this perspective, we review the state-of-the-art technology on establishing alveolar organoids from endogenous lung epithelial stem/progenitor cells or pluripotent stem cells, as well as the use of alveolar organoids for the study of respiratory diseases, including idiopathic pulmonary fibrosis, tuberculosis infection, and respiratory virus infection. We also discuss challenges that need to be overcome for future application of alveolar organoids in individualized medicine.http://dx.doi.org/10.1155/2020/5847876 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yu Li Qi Wu Xin Sun Jun Shen Huaiyong Chen |
spellingShingle |
Yu Li Qi Wu Xin Sun Jun Shen Huaiyong Chen Organoids as a Powerful Model for Respiratory Diseases Stem Cells International |
author_facet |
Yu Li Qi Wu Xin Sun Jun Shen Huaiyong Chen |
author_sort |
Yu Li |
title |
Organoids as a Powerful Model for Respiratory Diseases |
title_short |
Organoids as a Powerful Model for Respiratory Diseases |
title_full |
Organoids as a Powerful Model for Respiratory Diseases |
title_fullStr |
Organoids as a Powerful Model for Respiratory Diseases |
title_full_unstemmed |
Organoids as a Powerful Model for Respiratory Diseases |
title_sort |
organoids as a powerful model for respiratory diseases |
publisher |
Hindawi Limited |
series |
Stem Cells International |
issn |
1687-966X 1687-9678 |
publishDate |
2020-01-01 |
description |
Insults to the alveoli usually lead to inefficient gas exchange or even respiratory failure, which is difficult to model in animal studies. Over the past decade, stem cell-derived self-organizing three-dimensional organoids have emerged as a new avenue to recapitulate respiratory diseases in a dish. Alveolar organoids have improved our understanding of the mechanisms underlying tissue homeostasis and pathological alterations in alveoli. From this perspective, we review the state-of-the-art technology on establishing alveolar organoids from endogenous lung epithelial stem/progenitor cells or pluripotent stem cells, as well as the use of alveolar organoids for the study of respiratory diseases, including idiopathic pulmonary fibrosis, tuberculosis infection, and respiratory virus infection. We also discuss challenges that need to be overcome for future application of alveolar organoids in individualized medicine. |
url |
http://dx.doi.org/10.1155/2020/5847876 |
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