Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats
Biological factors that influence the host range and spillover of Ebola virus (EBOV) and other filoviruses remain enigmatic. While filoviruses infect diverse mammalian cell lines, we report that cells from African straw-colored fruit bats (Eidolon helvum) are refractory to EBOV infection. This could...
Main Authors: | Melinda Ng, Esther Ndungo, Maria E Kaczmarek, Andrew S Herbert, Tabea Binger, Ana I Kuehne, Rohit K Jangra, John A Hawkins, Robert J Gifford, Rohan Biswas, Ann Demogines, Rebekah M James, Meng Yu, Thijn R Brummelkamp, Christian Drosten, Lin-Fa Wang, Jens H Kuhn, Marcel A Müller, John M Dye, Sara L Sawyer, Kartik Chandran |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2015-12-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/11785 |
Similar Items
-
Niemann-Pick C1 (NPC1)/NPC1-like1 Chimeras Define Sequences Critical for NPC1’s Function as a Filovirus Entry Receptor
by: Esther Ndungo, et al.
Published: (2012-10-01) -
Structural Basis for Differential Neutralization of Ebolaviruses
by: John M. Dye, et al.
Published: (2012-04-01) -
Dendritic Cells Generated From Mops condylurus, a Likely Filovirus Reservoir Host, Are Susceptible to and Activated by Zaire Ebolavirus Infection
by: Kathryn M. Edenborough, et al.
Published: (2019-10-01) -
Filovirus tropism: Cellular molecules for viral entry
by: Ayato eTakada
Published: (2012-02-01) -
Filovirus RNA in Fruit Bats, China
by: Biao He, et al.
Published: (2015-09-01)