Multimodal analysis using [11C]PiB-PET/MRI for functional evaluation of patients with Alzheimer’s disease
Abstract Background Multimodal PET/MRI image data simultaneously obtained from patients with early-stage of Alzheimer’s disease (eAD) were assessed in order to observe pathophysiologic and functional changes, as well as alterations of morphology and connectivity in the brain. Fifty-eight patients wi...
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doaj-a4cb02f6b38244399e375b0e210b5ea42020-11-25T02:02:24ZengSpringerOpenEJNMMI Research2191-219X2020-03-0110111210.1186/s13550-020-00619-zMultimodal analysis using [11C]PiB-PET/MRI for functional evaluation of patients with Alzheimer’s diseaseHidehiko Okazawa0Masamichi Ikawa1Minyoung Jung2Rikiya Maruyama3Tetsuya Tsujikawa4Tetsuya Mori5Mahmudur G. M. Rahman6Akira Makino7Yasushi Kiyono8Hirotaka Kosaka9Biomedical Imaging Research Center, University of FukuiBiomedical Imaging Research Center, University of FukuiBiomedical Imaging Research Center, University of FukuiBiomedical Imaging Research Center, University of FukuiBiomedical Imaging Research Center, University of FukuiBiomedical Imaging Research Center, University of FukuiBiomedical Imaging Research Center, University of FukuiBiomedical Imaging Research Center, University of FukuiBiomedical Imaging Research Center, University of FukuiDepartment of Psychiatry, Faculty of Medical Sciences, University of FukuiAbstract Background Multimodal PET/MRI image data simultaneously obtained from patients with early-stage of Alzheimer’s disease (eAD) were assessed in order to observe pathophysiologic and functional changes, as well as alterations of morphology and connectivity in the brain. Fifty-eight patients with mild cognitive impairment and early dementia (29 males, 69 ± 12 years) underwent [11C]Pittsburgh compound-B (PiB) PET/MRI with 70-min PET and MRI scans. Sixteen age-matched healthy controls (CTL) (9 males, 68 ± 11 years) were also studied with the same scanning protocol. Cerebral blood flow (CBF) was calculated from the early phase PET images using the image-derived input function method. A standardized uptake value ratio (SUVr) was calculated from 50 to 70 min PET data with a reference region of the cerebellar cortex. MR images such as 3D-T1WI, resting-state functional MRI (RS-fMRI), diffusion tensor image (DTI), and perfusion MRI acquired during the dynamic PET scan were also analyzed to evaluate various brain functions on MRI. Results Twenty-seven of the 58 patients were determined as eAD based on the results of PiB-PET and clinical findings, and a total of 43 subjects’ data including CTL were analyzed in this study. PiB SUVr values in all cortical regions of eAD were significantly greater than those of CTL. The PiB accumulation intensity was negatively correlated with cognitive scores. The regional PET-CBF values of eAD were significantly lower in the bilateral parietal lobes and right temporal lobe compared with CTL, but not in MRI perfusion; however, SPM showed regional differences on both PET- and MRI-CBF. SPM analysis of RS-fMRI delineated regional differences between the groups in the anterior cingulate cortex and the left precuneus. VBM analysis showed atrophic changes in the AD group in a part of the bilateral hippocampus; however, analysis of fractional anisotropy calculated from DTI data did not show differences between the two groups. Conclusion Multimodal analysis conducted with various image data from PiB-PET/MRI scans showed differences in regional CBF, cortical volume, and neuronal networks in different regions, indicating that pathophysiologic and functional changes in the AD brain can be observed from various aspects of neurophysiologic parameters. Application of multimodal brain images using PET/MRI would be ideal for investigating pathophysiologic changes in patients with dementia and other neurodegenerative diseases.http://link.springer.com/article/10.1186/s13550-020-00619-zPET/MRIAmyloid imagingCerebral blood flowFunctional MRIQuantitative analysisMultimodal analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hidehiko Okazawa Masamichi Ikawa Minyoung Jung Rikiya Maruyama Tetsuya Tsujikawa Tetsuya Mori Mahmudur G. M. Rahman Akira Makino Yasushi Kiyono Hirotaka Kosaka |
spellingShingle |
Hidehiko Okazawa Masamichi Ikawa Minyoung Jung Rikiya Maruyama Tetsuya Tsujikawa Tetsuya Mori Mahmudur G. M. Rahman Akira Makino Yasushi Kiyono Hirotaka Kosaka Multimodal analysis using [11C]PiB-PET/MRI for functional evaluation of patients with Alzheimer’s disease EJNMMI Research PET/MRI Amyloid imaging Cerebral blood flow Functional MRI Quantitative analysis Multimodal analysis |
author_facet |
Hidehiko Okazawa Masamichi Ikawa Minyoung Jung Rikiya Maruyama Tetsuya Tsujikawa Tetsuya Mori Mahmudur G. M. Rahman Akira Makino Yasushi Kiyono Hirotaka Kosaka |
author_sort |
Hidehiko Okazawa |
title |
Multimodal analysis using [11C]PiB-PET/MRI for functional evaluation of patients with Alzheimer’s disease |
title_short |
Multimodal analysis using [11C]PiB-PET/MRI for functional evaluation of patients with Alzheimer’s disease |
title_full |
Multimodal analysis using [11C]PiB-PET/MRI for functional evaluation of patients with Alzheimer’s disease |
title_fullStr |
Multimodal analysis using [11C]PiB-PET/MRI for functional evaluation of patients with Alzheimer’s disease |
title_full_unstemmed |
Multimodal analysis using [11C]PiB-PET/MRI for functional evaluation of patients with Alzheimer’s disease |
title_sort |
multimodal analysis using [11c]pib-pet/mri for functional evaluation of patients with alzheimer’s disease |
publisher |
SpringerOpen |
series |
EJNMMI Research |
issn |
2191-219X |
publishDate |
2020-03-01 |
description |
Abstract Background Multimodal PET/MRI image data simultaneously obtained from patients with early-stage of Alzheimer’s disease (eAD) were assessed in order to observe pathophysiologic and functional changes, as well as alterations of morphology and connectivity in the brain. Fifty-eight patients with mild cognitive impairment and early dementia (29 males, 69 ± 12 years) underwent [11C]Pittsburgh compound-B (PiB) PET/MRI with 70-min PET and MRI scans. Sixteen age-matched healthy controls (CTL) (9 males, 68 ± 11 years) were also studied with the same scanning protocol. Cerebral blood flow (CBF) was calculated from the early phase PET images using the image-derived input function method. A standardized uptake value ratio (SUVr) was calculated from 50 to 70 min PET data with a reference region of the cerebellar cortex. MR images such as 3D-T1WI, resting-state functional MRI (RS-fMRI), diffusion tensor image (DTI), and perfusion MRI acquired during the dynamic PET scan were also analyzed to evaluate various brain functions on MRI. Results Twenty-seven of the 58 patients were determined as eAD based on the results of PiB-PET and clinical findings, and a total of 43 subjects’ data including CTL were analyzed in this study. PiB SUVr values in all cortical regions of eAD were significantly greater than those of CTL. The PiB accumulation intensity was negatively correlated with cognitive scores. The regional PET-CBF values of eAD were significantly lower in the bilateral parietal lobes and right temporal lobe compared with CTL, but not in MRI perfusion; however, SPM showed regional differences on both PET- and MRI-CBF. SPM analysis of RS-fMRI delineated regional differences between the groups in the anterior cingulate cortex and the left precuneus. VBM analysis showed atrophic changes in the AD group in a part of the bilateral hippocampus; however, analysis of fractional anisotropy calculated from DTI data did not show differences between the two groups. Conclusion Multimodal analysis conducted with various image data from PiB-PET/MRI scans showed differences in regional CBF, cortical volume, and neuronal networks in different regions, indicating that pathophysiologic and functional changes in the AD brain can be observed from various aspects of neurophysiologic parameters. Application of multimodal brain images using PET/MRI would be ideal for investigating pathophysiologic changes in patients with dementia and other neurodegenerative diseases. |
topic |
PET/MRI Amyloid imaging Cerebral blood flow Functional MRI Quantitative analysis Multimodal analysis |
url |
http://link.springer.com/article/10.1186/s13550-020-00619-z |
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