Distinctive lung function trajectories from age 10 to 26 years in men and women and associated early life risk factors – a birth cohort study
Abstract Pre-bronchodilator lung function including forced vital capacity (FVC), forced expiratory flow in 1 second (FEV1), their ratio (FEV1/FVC), and forced expiratory flow 25–75% (FEF25–75) measured at age 10, 18, and 26 years in the Isle of Wight birth cohort was analyzed for developmental patte...
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doaj-a4cba0afa76f42f2ae11cc6db942cda32020-11-25T02:57:39ZengBMCRespiratory Research1465-993X2019-05-0120111310.1186/s12931-019-1068-0Distinctive lung function trajectories from age 10 to 26 years in men and women and associated early life risk factors – a birth cohort studyWilfried Karmaus0Nandini Mukherjee1Vimala Devi Janjanam2Su Chen3Hongmei Zhang4Graham Roberts5Ramesh J. Kurukulaaratchy6Hasan Arshad7Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of MemphisDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of MemphisDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of MemphisDepartment of Mathematical Sciences, The University of MemphisDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of MemphisPaediatric Allergy and Respiratory Medicine, Faculty of Medicine, University of SouthamptonClinical and Experimental Sciences, Faculty of Medicine, University of SouthamptonClinical and Experimental Sciences, Faculty of Medicine, University of SouthamptonAbstract Pre-bronchodilator lung function including forced vital capacity (FVC), forced expiratory flow in 1 second (FEV1), their ratio (FEV1/FVC), and forced expiratory flow 25–75% (FEF25–75) measured at age 10, 18, and 26 years in the Isle of Wight birth cohort was analyzed for developmental patterns (trajectories). Early life risk factors before the age of 10 years were assessed for the trajectories. Method Members of the birth cohort (1989/90) were followed at age 1, 2, 4, 10, 18, and 26 years. Allergic sensitization and questionnaire data were collected. Spirometry tests were performed and evaluated according to the American Thoracic Society (ATS) criteria at 10, 18, and 26 years. To identify developmental trajectories for FVC, FEV1, FEV1/FVC, and FEF25–75 from 10 to 26 years, a finite mixture model was applied to the longitudinal lung function data, separately for males and females. Associations of early life factors with the respective lung function trajectories were assessed using log-linear and logistic regression analyses. Results Both high and low lung function trajectories were observed in men and women. FVC continued to grow beyond 18 years in men and women, whereas FEV1 peaked at age 18 years in female trajectories and in one male trajectory. For the FEV1/FVC ratios and FEF25–75 most trajectories appeared highest at age 18 and declined thereafter. However, the low FEV1/FVC trajectory in both sexes showed an early decline at 10 years. Lower birth weight was linked with lower lung function trajectories in males and females. Eczema in the first year of life was a risk factor for later lung function deficits in females, whereas the occurrence of asthma at 4 years of age was a risk factor for later lung function deficits in males. A positive skin prick test at age four was a risk for the low FEV1 trajectory in females and for the low FEV1/FVC trajectory in males. Conclusion Men and women showed distinctive lung function trajectories and associated risk factors. Lower lung function trajectories can be explained by not achieving maximally attainable function at age 18 years and by a function decline from 18 to 26 years.http://link.springer.com/article/10.1186/s12931-019-1068-0 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wilfried Karmaus Nandini Mukherjee Vimala Devi Janjanam Su Chen Hongmei Zhang Graham Roberts Ramesh J. Kurukulaaratchy Hasan Arshad |
spellingShingle |
Wilfried Karmaus Nandini Mukherjee Vimala Devi Janjanam Su Chen Hongmei Zhang Graham Roberts Ramesh J. Kurukulaaratchy Hasan Arshad Distinctive lung function trajectories from age 10 to 26 years in men and women and associated early life risk factors – a birth cohort study Respiratory Research |
author_facet |
Wilfried Karmaus Nandini Mukherjee Vimala Devi Janjanam Su Chen Hongmei Zhang Graham Roberts Ramesh J. Kurukulaaratchy Hasan Arshad |
author_sort |
Wilfried Karmaus |
title |
Distinctive lung function trajectories from age 10 to 26 years in men and women and associated early life risk factors – a birth cohort study |
title_short |
Distinctive lung function trajectories from age 10 to 26 years in men and women and associated early life risk factors – a birth cohort study |
title_full |
Distinctive lung function trajectories from age 10 to 26 years in men and women and associated early life risk factors – a birth cohort study |
title_fullStr |
Distinctive lung function trajectories from age 10 to 26 years in men and women and associated early life risk factors – a birth cohort study |
title_full_unstemmed |
Distinctive lung function trajectories from age 10 to 26 years in men and women and associated early life risk factors – a birth cohort study |
title_sort |
distinctive lung function trajectories from age 10 to 26 years in men and women and associated early life risk factors – a birth cohort study |
publisher |
BMC |
series |
Respiratory Research |
issn |
1465-993X |
publishDate |
2019-05-01 |
description |
Abstract Pre-bronchodilator lung function including forced vital capacity (FVC), forced expiratory flow in 1 second (FEV1), their ratio (FEV1/FVC), and forced expiratory flow 25–75% (FEF25–75) measured at age 10, 18, and 26 years in the Isle of Wight birth cohort was analyzed for developmental patterns (trajectories). Early life risk factors before the age of 10 years were assessed for the trajectories. Method Members of the birth cohort (1989/90) were followed at age 1, 2, 4, 10, 18, and 26 years. Allergic sensitization and questionnaire data were collected. Spirometry tests were performed and evaluated according to the American Thoracic Society (ATS) criteria at 10, 18, and 26 years. To identify developmental trajectories for FVC, FEV1, FEV1/FVC, and FEF25–75 from 10 to 26 years, a finite mixture model was applied to the longitudinal lung function data, separately for males and females. Associations of early life factors with the respective lung function trajectories were assessed using log-linear and logistic regression analyses. Results Both high and low lung function trajectories were observed in men and women. FVC continued to grow beyond 18 years in men and women, whereas FEV1 peaked at age 18 years in female trajectories and in one male trajectory. For the FEV1/FVC ratios and FEF25–75 most trajectories appeared highest at age 18 and declined thereafter. However, the low FEV1/FVC trajectory in both sexes showed an early decline at 10 years. Lower birth weight was linked with lower lung function trajectories in males and females. Eczema in the first year of life was a risk factor for later lung function deficits in females, whereas the occurrence of asthma at 4 years of age was a risk factor for later lung function deficits in males. A positive skin prick test at age four was a risk for the low FEV1 trajectory in females and for the low FEV1/FVC trajectory in males. Conclusion Men and women showed distinctive lung function trajectories and associated risk factors. Lower lung function trajectories can be explained by not achieving maximally attainable function at age 18 years and by a function decline from 18 to 26 years. |
url |
http://link.springer.com/article/10.1186/s12931-019-1068-0 |
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