Clinical significance of coagulation function combined with blood gas analysis and serum NT-proBNP detection in COPD patients

• Main Authors: Li-Hua Yu, Yong-Chang Wu
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-02-01
• Series: Journal of Hainan Medical University
• Subjects: COPD; NT-proBNP; Coagulation function; Blood gas analysis; D-D
• Online Access: http://www.hnykdxxb.com/PDF/201702/13.pdf

Objective: To investigate the clinical significance of coagulation function, blood gas analysis and serum N-terminal pro-brain natriuretic peptide (NT-proBNP) level detection in patients with chronic obstructive pulmonary disease (COPD). Methods: A total of 98 cases of COPD patients were selected and divided per different disease courses. For COPD acute exacerbation (AECOPD) stage, 53 patients were selected and set as group A. 45 cases of COPD patients in COPD stable stage were set as group B, and 50 cases of healthy people who received physical examination in our hospital in the corresponding period were collected and set as healthy controls (group C). Levels of PT, APTT, TT, Fbg, D-D, PaCO2, PaO2 and serum NTproBNP in the whole 3 groups of patients were detected. Differences of index levels among the 3 groups and between before and after treatment in AECOPD patients were compared separately. The correlations of NT-proBNP, coagulation relevant indexes and arterial blood gas relevant indexes were analyzed. Results: (1) PT, APTT in group A and PT, APTT in group B were obviously longer than which in group C, and group A showed more significant variations. (2) Fbg, D-D, PaCO2 , NT-proBNP in group A and Fbg, D-D, PaCO2, NT-proBNP in group B were obviously higher than which in group C; But PaO2 in group A and PaO2 in group B were significantly lower than which in group C; Group A showed more significant variations. (3) After treatment, PT and APTT in AECOPD patients were shorter than which before treatment, Fbg, D-D, PaCO2 and NT-proBNP were lower than before treatment, but PaO2 was higher than before treatment. (4) TT in group A were significantly longer than in group C, and differences showed no significance on comparison of TT between patients of group A and B, B and C and within A before and after treatment. (5) NT-proBNP in COPD patients showed significantly positive correlation separately with APTT, Fbg, D-D and PaCO2, showed significantly negative correlation with PaO2, but showed no obvious correlation with PT. Conclusion: Coagulation function and blood gas analysis combined with serum NT-proBNP level detection could better judge the severity of COPD. It shows significant reference value on clinical diagnosis, disease monitoring and evaluation for COPD patients.