Cannabinoid Receptor Interacting Protein 1a (CRIP1a) in Health and Disease
Endocannabinoid signaling depends upon the CB<sub>1</sub> and CB<sub>2</sub> cannabinoid receptors, their endogenous ligands anandamide and 2-arachidonoylglycerol, and intracellular proteins that mediate responses via the C-terminal and other intracellular receptor domains. T...
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MDPI AG
2020-11-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/10/12/1609 |
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doaj-a509d5d9c3f1441cb33ae19fba76deae2020-11-28T00:04:36ZengMDPI AGBiomolecules2218-273X2020-11-01101609160910.3390/biom10121609Cannabinoid Receptor Interacting Protein 1a (CRIP1a) in Health and DiseaseEmily E. Oliver0Erin K. Hughes1Meaghan K. Puckett2Rong Chen3W. Todd Lowther4Allyn C. Howlett5Department of Physiology and Pharmacology, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 20157, USADepartment of Physiology and Pharmacology, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 20157, USADepartment of Physiology and Pharmacology, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 20157, USADepartment of Physiology and Pharmacology, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 20157, USADepartment of Biochemistry and Center for Structural Biology, Wake Forest School of Medicine, Winston-Salem, NC 20157, USADepartment of Physiology and Pharmacology, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 20157, USAEndocannabinoid signaling depends upon the CB<sub>1</sub> and CB<sub>2</sub> cannabinoid receptors, their endogenous ligands anandamide and 2-arachidonoylglycerol, and intracellular proteins that mediate responses via the C-terminal and other intracellular receptor domains. The CB<sub>1</sub> receptor regulates and is regulated by associated G proteins predominantly of the Gi/o subtypes, β-arrestins 1 and 2, and the cannabinoid receptor-interacting protein 1a (CRIP1a). Evidence for a physiological role for CRIP1a is emerging as data regarding the cellular localization and function of CRIP1a are generated. Here we summarize the neuronal distribution and role of CRIP1a in endocannabinoid signaling, as well as discuss investigations linking CRIP1a to development, vision and hearing sensory systems, hippocampus and seizure regulation, and psychiatric disorders including schizophrenia. We also examine the genetic and epigenetic association of CRIP1a within a variety of cancer subtypes. This review provides evidence upon which to base future investigations on the function of CRIP1a in health and disease.https://www.mdpi.com/2218-273X/10/12/1609cancerembryonic developmentendocannabinoidsepilepsyG protein-coupled receptors (GPCRs), hippocampusretina |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Emily E. Oliver Erin K. Hughes Meaghan K. Puckett Rong Chen W. Todd Lowther Allyn C. Howlett |
| spellingShingle |
Emily E. Oliver Erin K. Hughes Meaghan K. Puckett Rong Chen W. Todd Lowther Allyn C. Howlett Cannabinoid Receptor Interacting Protein 1a (CRIP1a) in Health and Disease Biomolecules cancer embryonic development endocannabinoids epilepsy G protein-coupled receptors (GPCRs), hippocampus retina |
| author_facet |
Emily E. Oliver Erin K. Hughes Meaghan K. Puckett Rong Chen W. Todd Lowther Allyn C. Howlett |
| author_sort |
Emily E. Oliver |
| title |
Cannabinoid Receptor Interacting Protein 1a (CRIP1a) in Health and Disease |
| title_short |
Cannabinoid Receptor Interacting Protein 1a (CRIP1a) in Health and Disease |
| title_full |
Cannabinoid Receptor Interacting Protein 1a (CRIP1a) in Health and Disease |
| title_fullStr |
Cannabinoid Receptor Interacting Protein 1a (CRIP1a) in Health and Disease |
| title_full_unstemmed |
Cannabinoid Receptor Interacting Protein 1a (CRIP1a) in Health and Disease |
| title_sort |
cannabinoid receptor interacting protein 1a (crip1a) in health and disease |
| publisher |
MDPI AG |
| series |
Biomolecules |
| issn |
2218-273X |
| publishDate |
2020-11-01 |
| description |
Endocannabinoid signaling depends upon the CB<sub>1</sub> and CB<sub>2</sub> cannabinoid receptors, their endogenous ligands anandamide and 2-arachidonoylglycerol, and intracellular proteins that mediate responses via the C-terminal and other intracellular receptor domains. The CB<sub>1</sub> receptor regulates and is regulated by associated G proteins predominantly of the Gi/o subtypes, β-arrestins 1 and 2, and the cannabinoid receptor-interacting protein 1a (CRIP1a). Evidence for a physiological role for CRIP1a is emerging as data regarding the cellular localization and function of CRIP1a are generated. Here we summarize the neuronal distribution and role of CRIP1a in endocannabinoid signaling, as well as discuss investigations linking CRIP1a to development, vision and hearing sensory systems, hippocampus and seizure regulation, and psychiatric disorders including schizophrenia. We also examine the genetic and epigenetic association of CRIP1a within a variety of cancer subtypes. This review provides evidence upon which to base future investigations on the function of CRIP1a in health and disease. |
| topic |
cancer embryonic development endocannabinoids epilepsy G protein-coupled receptors (GPCRs), hippocampus retina |
| url |
https://www.mdpi.com/2218-273X/10/12/1609 |
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