Sijunzi, Lizhong, and Fuzilizhong Decoction Alleviate Nonalcoholic Fatty Liver Disease through Activation of PPAR Pathway
Objective. Sijunzi, Lizhong, and Fuzilizhong decoction were traditional Chinese classic formulations, which are widely used in clinical treatment, and the underlying mechanism is unclear. In this study, we aim to investigate the molecular mechanisms underlying the protective effects of Sijunzi, Lizh...
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doaj-a50d4e8398c446f6a40a9ae20357dea12020-11-25T04:09:40ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882020-01-01202010.1155/2020/63637486363748Sijunzi, Lizhong, and Fuzilizhong Decoction Alleviate Nonalcoholic Fatty Liver Disease through Activation of PPAR PathwayJiayao Yang0Dongqing Tao1Wei Ma2Song Liu3Yan Liao4Lei Shu5Shu Zhang6Chenyu Li7Nianlong Du8Zhaohong Shi9Department of Gastroenterology, Wuhan Integrated TCM and Western Medicine Hospital, Wuhan, ChinaDepartment of Endocrinology, The Third People’s Hospital of Hubei Province, Wuhan, ChinaDepartment of Center Laboratory, Wuhan Integrated TCM and Western Medicine Hospital, Wuhan, ChinaDepartment of Gastroenterology, Wuhan Integrated TCM and Western Medicine Hospital, Wuhan, ChinaDepartment of Gastroenterology, Wuhan Integrated TCM and Western Medicine Hospital, Wuhan, ChinaDepartment of Gastroenterology, Wuhan Integrated TCM and Western Medicine Hospital, Wuhan, ChinaDepartment of Gastroenterology, Wuhan Integrated TCM and Western Medicine Hospital, Wuhan, ChinaHubei University of Traditional Chinese Medicine, Wuhan, ChinaDepartment of Gastroenterology, Wuhan Integrated TCM and Western Medicine Hospital, Wuhan, ChinaDepartment of Gastroenterology, Wuhan Integrated TCM and Western Medicine Hospital, Wuhan, ChinaObjective. Sijunzi, Lizhong, and Fuzilizhong decoction were traditional Chinese classic formulations, which are widely used in clinical treatment, and the underlying mechanism is unclear. In this study, we aim to investigate the molecular mechanisms underlying the protective effects of Sijunzi, Lizhong, and Fuzilizhong on nonalcoholic fatty liver disease (NAFLD). Methods. Male Wistar rats were fed a high-fat diet for four weeks to induce NAFLD and were thereafter administered Sijunzi (8 g/kg/d), Lizhong (10 g/kg/d), or Fuzilizhong (10 g/kg/d) by gavage for four weeks. Hepatic damage, lipid accumulation, inflammation, autophagy, and peroxisome proliferator-activated receptor-α signaling were evaluated. Results. The high-fat diet-fed rats showed typical symptoms of NAFLD, including elevated levels of hepatic damage indicators, increased hepatic lipid deposition and fibrosis, severe liver inflammation, and prominent autophagy. Upon administration of Sijunzi, Lizhong, and Fuzilizhong, liver health was improved remarkably, along with ameliorated symptoms of NAFLD. In addition, NAFLD-suppressed peroxisome proliferator-activated receptor-α signaling was reactivated after treatment with the three types of decoctions. Conclusions. The results collectively signify the effective therapeutic and protective functions of Sijunzi, Lizhong, and Fuzilizhong against NAFLD and demonstrate the potential of Chinese herbal medication in mitigating the symptoms of liver diseases. Novelty of the Work. Traditional Chinese herbal medicine has been used for centuries to treat various diseases, but the molecular mechanisms of individual ingredients have rarely been studied. The novelty of our work lies in elucidating the specific signaling pathways involved in the control of NAFLD using three common Chinese herbal decoctions. We suggest that natural herbal formulations can be effective therapeutic agents to combat against NAFLD.http://dx.doi.org/10.1155/2020/6363748 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jiayao Yang Dongqing Tao Wei Ma Song Liu Yan Liao Lei Shu Shu Zhang Chenyu Li Nianlong Du Zhaohong Shi |
spellingShingle |
Jiayao Yang Dongqing Tao Wei Ma Song Liu Yan Liao Lei Shu Shu Zhang Chenyu Li Nianlong Du Zhaohong Shi Sijunzi, Lizhong, and Fuzilizhong Decoction Alleviate Nonalcoholic Fatty Liver Disease through Activation of PPAR Pathway Evidence-Based Complementary and Alternative Medicine |
author_facet |
Jiayao Yang Dongqing Tao Wei Ma Song Liu Yan Liao Lei Shu Shu Zhang Chenyu Li Nianlong Du Zhaohong Shi |
author_sort |
Jiayao Yang |
title |
Sijunzi, Lizhong, and Fuzilizhong Decoction Alleviate Nonalcoholic Fatty Liver Disease through Activation of PPAR Pathway |
title_short |
Sijunzi, Lizhong, and Fuzilizhong Decoction Alleviate Nonalcoholic Fatty Liver Disease through Activation of PPAR Pathway |
title_full |
Sijunzi, Lizhong, and Fuzilizhong Decoction Alleviate Nonalcoholic Fatty Liver Disease through Activation of PPAR Pathway |
title_fullStr |
Sijunzi, Lizhong, and Fuzilizhong Decoction Alleviate Nonalcoholic Fatty Liver Disease through Activation of PPAR Pathway |
title_full_unstemmed |
Sijunzi, Lizhong, and Fuzilizhong Decoction Alleviate Nonalcoholic Fatty Liver Disease through Activation of PPAR Pathway |
title_sort |
sijunzi, lizhong, and fuzilizhong decoction alleviate nonalcoholic fatty liver disease through activation of ppar pathway |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2020-01-01 |
description |
Objective. Sijunzi, Lizhong, and Fuzilizhong decoction were traditional Chinese classic formulations, which are widely used in clinical treatment, and the underlying mechanism is unclear. In this study, we aim to investigate the molecular mechanisms underlying the protective effects of Sijunzi, Lizhong, and Fuzilizhong on nonalcoholic fatty liver disease (NAFLD). Methods. Male Wistar rats were fed a high-fat diet for four weeks to induce NAFLD and were thereafter administered Sijunzi (8 g/kg/d), Lizhong (10 g/kg/d), or Fuzilizhong (10 g/kg/d) by gavage for four weeks. Hepatic damage, lipid accumulation, inflammation, autophagy, and peroxisome proliferator-activated receptor-α signaling were evaluated. Results. The high-fat diet-fed rats showed typical symptoms of NAFLD, including elevated levels of hepatic damage indicators, increased hepatic lipid deposition and fibrosis, severe liver inflammation, and prominent autophagy. Upon administration of Sijunzi, Lizhong, and Fuzilizhong, liver health was improved remarkably, along with ameliorated symptoms of NAFLD. In addition, NAFLD-suppressed peroxisome proliferator-activated receptor-α signaling was reactivated after treatment with the three types of decoctions. Conclusions. The results collectively signify the effective therapeutic and protective functions of Sijunzi, Lizhong, and Fuzilizhong against NAFLD and demonstrate the potential of Chinese herbal medication in mitigating the symptoms of liver diseases. Novelty of the Work. Traditional Chinese herbal medicine has been used for centuries to treat various diseases, but the molecular mechanisms of individual ingredients have rarely been studied. The novelty of our work lies in elucidating the specific signaling pathways involved in the control of NAFLD using three common Chinese herbal decoctions. We suggest that natural herbal formulations can be effective therapeutic agents to combat against NAFLD. |
url |
http://dx.doi.org/10.1155/2020/6363748 |
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