The Salmonella deubiquitinase SseL inhibits selective autophagy of cytosolic aggregates.
Cell stress and infection promote the formation of ubiquitinated aggregates in both non-immune and immune cells. These structures are recognised by the autophagy receptor p62/sequestosome 1 and are substrates for selective autophagy. The intracellular growth of Salmonella enterica occurs in a membra...
Main Authors: | Francisco S Mesquita, Mair Thomas, Martin Sachse, António J M Santos, Rita Figueira, David W Holden |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC3375275?pdf=render |
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