Computational identification of self-inhibitory peptides from white spot syndrome virus envelope protein VP28
Since effective chemotherapeutics or preventive measures are still unavailable, finding feasible approaches against white spot syndrome virus (WSSV) has always been the vital subject in shrimp farming field. Envelope proteins are the ideal targets for antiviral strategies development due to their in...
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doaj-a51ab30d6336442ea7e045864feee18c2020-11-25T02:11:41ZengElsevierAquaculture Reports2352-51342019-07-0114Computational identification of self-inhibitory peptides from white spot syndrome virus envelope protein VP28Yongzhong Lu0Qian Qiu1Chen Li2Linyue Cheng3Jie Liu4Shandong Provincial Key Laboratory of Biochemical Engineering, Qingdao University of Science and Technology, No. 53, Zhengzhou Road, 266042, Qingdao, China; Corresponding author.Shandong Provincial Key Laboratory of Biochemical Engineering, Qingdao University of Science and Technology, No. 53, Zhengzhou Road, 266042, Qingdao, ChinaYellow Sea Fisheries Research Institute, Chinese Academy Of Fishery Sciences, No. 106, Nanjing Road, 266071, Qingdao, ChinaShandong Provincial Key Laboratory of Biochemical Engineering, Qingdao University of Science and Technology, No. 53, Zhengzhou Road, 266042, Qingdao, ChinaShandong Provincial Key Laboratory of Biochemical Engineering, Qingdao University of Science and Technology, No. 53, Zhengzhou Road, 266042, Qingdao, ChinaSince effective chemotherapeutics or preventive measures are still unavailable, finding feasible approaches against white spot syndrome virus (WSSV) has always been the vital subject in shrimp farming field. Envelope proteins are the ideal targets for antiviral strategies development due to their indispensable roles in virus entry, and inhibitory peptides targeting them have been proved to be promising in blocking virus infection. In this study, the Wimley-White interfacial hydrophobicity scale (WWIHS) in combination with known structural data was applied to identify potential inhibitory peptides that targeted the envelope protein VP28 of WSSV. Results showed that two potential inhibitory peptides were identified, one of which exhibited not only obvious antiviral activity, but also broad-spectrum antimicrobial activity. The inhibitory peptide identified here can serve as a lead compound for anti-WSSV strategies development. Keywords: Envelope protein, Inhibitory peptide, White spot syndrome virus, Shrimphttp://www.sciencedirect.com/science/article/pii/S2352513419300067 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yongzhong Lu Qian Qiu Chen Li Linyue Cheng Jie Liu |
spellingShingle |
Yongzhong Lu Qian Qiu Chen Li Linyue Cheng Jie Liu Computational identification of self-inhibitory peptides from white spot syndrome virus envelope protein VP28 Aquaculture Reports |
author_facet |
Yongzhong Lu Qian Qiu Chen Li Linyue Cheng Jie Liu |
author_sort |
Yongzhong Lu |
title |
Computational identification of self-inhibitory peptides from white spot syndrome virus envelope protein VP28 |
title_short |
Computational identification of self-inhibitory peptides from white spot syndrome virus envelope protein VP28 |
title_full |
Computational identification of self-inhibitory peptides from white spot syndrome virus envelope protein VP28 |
title_fullStr |
Computational identification of self-inhibitory peptides from white spot syndrome virus envelope protein VP28 |
title_full_unstemmed |
Computational identification of self-inhibitory peptides from white spot syndrome virus envelope protein VP28 |
title_sort |
computational identification of self-inhibitory peptides from white spot syndrome virus envelope protein vp28 |
publisher |
Elsevier |
series |
Aquaculture Reports |
issn |
2352-5134 |
publishDate |
2019-07-01 |
description |
Since effective chemotherapeutics or preventive measures are still unavailable, finding feasible approaches against white spot syndrome virus (WSSV) has always been the vital subject in shrimp farming field. Envelope proteins are the ideal targets for antiviral strategies development due to their indispensable roles in virus entry, and inhibitory peptides targeting them have been proved to be promising in blocking virus infection. In this study, the Wimley-White interfacial hydrophobicity scale (WWIHS) in combination with known structural data was applied to identify potential inhibitory peptides that targeted the envelope protein VP28 of WSSV. Results showed that two potential inhibitory peptides were identified, one of which exhibited not only obvious antiviral activity, but also broad-spectrum antimicrobial activity. The inhibitory peptide identified here can serve as a lead compound for anti-WSSV strategies development. Keywords: Envelope protein, Inhibitory peptide, White spot syndrome virus, Shrimp |
url |
http://www.sciencedirect.com/science/article/pii/S2352513419300067 |
work_keys_str_mv |
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