Improved synthesis of [18F] fallypride and characterization of a Huntington’s disease mouse model, zQ175DN KI, using longitudinal PET imaging of D2/D3 receptors

Improved synthesis of [18F] fallypride and characterization of a Huntington’s disease mouse model, zQ175DN KI, using longitudinal PET imaging of D2/D3 receptors

Abstract Purpose Dopamine receptors are involved in pathophysiology of neuropsychiatric diseases, including Huntington’s disease (HD). PET imaging of dopamine D2 receptors (D2R) in HD patients has demonstrated 40% decrease in D2R binding in striatum, and D2R could be a reliable quantitative target t...

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Bibliographic Details
Main Authors: Tuulia Huhtala, Pekka Poutiainen, Jussi Rytkönen, Kimmo Lehtimäki, Teija Parkkari, Iiris Kasanen, Anu J. Airaksinen, Teija Koivula, Patrick Sweeney, Outi Kontkanen, John Wityak, Celia Dominiquez, Larry C. Park
Format: Article
Language:English
Published: SpringerOpen 2019-08-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
Huntington’s disease
[18F] fallypride
PET
Autoradiography
Translational imaging
Online Access:http://link.springer.com/article/10.1186/s41181-019-0071-6

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