<i>Drosophila</i> Gut—A Nexus Between Dietary Restriction and Lifespan
Aging is often defined as the accumulation of damage at the molecular and cellular levels which, over time, results in marked physiological impairments throughout the organism. Dietary restriction (DR) has been recognized as one of the strongest lifespan extending therapies observed in a wide array...
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doaj-a528e64ecf7941fea40811b50e69ee682020-11-24T23:58:06ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-11-011912381010.3390/ijms19123810ijms19123810<i>Drosophila</i> Gut—A Nexus Between Dietary Restriction and LifespanTing Lian0Qi Wu1Brian A. Hodge2Kenneth A. Wilson3Guixiang Yu4Mingyao Yang5Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, ChinaInstitute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, ChinaBuck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA 94947, USABuck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA 94947, USAInstitute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, ChinaInstitute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, ChinaAging is often defined as the accumulation of damage at the molecular and cellular levels which, over time, results in marked physiological impairments throughout the organism. Dietary restriction (DR) has been recognized as one of the strongest lifespan extending therapies observed in a wide array of organisms. Recent studies aimed at elucidating how DR promotes healthy aging have demonstrated a vital role of the digestive tract in mediating the beneficial effects of DR. Here, we review how dietary restriction influences gut metabolic homeostasis and immune function. Our discussion is focused on studies of the <i>Drosophila</i> digestive tract, where we describe in detail the potential mechanisms in which DR enhances maintenance of the intestinal epithelial barrier, up-regulates lipid metabolic processes, and improves the ability of the gut to deal with damage or stress. We also examine evidence of a tissue-tissue crosstalk between gut and neighboring organs including brain and fat body. Taken together, we argue that the <i>Drosophila</i> gut plays a critical role in DR-mediated lifespan extension.https://www.mdpi.com/1422-0067/19/12/3810<i>Drosophila</i>gutagingdietary restrictionintestinal epithelia barrier |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ting Lian Qi Wu Brian A. Hodge Kenneth A. Wilson Guixiang Yu Mingyao Yang |
spellingShingle |
Ting Lian Qi Wu Brian A. Hodge Kenneth A. Wilson Guixiang Yu Mingyao Yang <i>Drosophila</i> Gut—A Nexus Between Dietary Restriction and Lifespan International Journal of Molecular Sciences <i>Drosophila</i> gut aging dietary restriction intestinal epithelia barrier |
author_facet |
Ting Lian Qi Wu Brian A. Hodge Kenneth A. Wilson Guixiang Yu Mingyao Yang |
author_sort |
Ting Lian |
title |
<i>Drosophila</i> Gut—A Nexus Between Dietary Restriction and Lifespan |
title_short |
<i>Drosophila</i> Gut—A Nexus Between Dietary Restriction and Lifespan |
title_full |
<i>Drosophila</i> Gut—A Nexus Between Dietary Restriction and Lifespan |
title_fullStr |
<i>Drosophila</i> Gut—A Nexus Between Dietary Restriction and Lifespan |
title_full_unstemmed |
<i>Drosophila</i> Gut—A Nexus Between Dietary Restriction and Lifespan |
title_sort |
<i>drosophila</i> gut—a nexus between dietary restriction and lifespan |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2018-11-01 |
description |
Aging is often defined as the accumulation of damage at the molecular and cellular levels which, over time, results in marked physiological impairments throughout the organism. Dietary restriction (DR) has been recognized as one of the strongest lifespan extending therapies observed in a wide array of organisms. Recent studies aimed at elucidating how DR promotes healthy aging have demonstrated a vital role of the digestive tract in mediating the beneficial effects of DR. Here, we review how dietary restriction influences gut metabolic homeostasis and immune function. Our discussion is focused on studies of the <i>Drosophila</i> digestive tract, where we describe in detail the potential mechanisms in which DR enhances maintenance of the intestinal epithelial barrier, up-regulates lipid metabolic processes, and improves the ability of the gut to deal with damage or stress. We also examine evidence of a tissue-tissue crosstalk between gut and neighboring organs including brain and fat body. Taken together, we argue that the <i>Drosophila</i> gut plays a critical role in DR-mediated lifespan extension. |
topic |
<i>Drosophila</i> gut aging dietary restriction intestinal epithelia barrier |
url |
https://www.mdpi.com/1422-0067/19/12/3810 |
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