Pancreatic paraganglioma: An extremely rare entity and crucial role of immunohistochemistry for diagnosis
Paragangliomas are rare neuroendocrine neoplasms arising in extra-adrenal chromaffin cells of autonomic nervous system and histologically akin to chemodectomas. They are rare, affecting about 1 in 2,000,000 population. It is a generic term applied to tumors of paraganglia regardless of the location....
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Wolters Kluwer Medknow Publications
2013-01-01
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doaj-a53182b484a7440ba50cdfe825a0e8112020-11-25T00:00:46ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102230-95002013-01-0117591791910.4103/2230-8210.117217Pancreatic paraganglioma: An extremely rare entity and crucial role of immunohistochemistry for diagnosisMondita BorgohainGayatri GogoiDipak DasManjusha BiswasParagangliomas are rare neuroendocrine neoplasms arising in extra-adrenal chromaffin cells of autonomic nervous system and histologically akin to chemodectomas. They are rare, affecting about 1 in 2,000,000 population. It is a generic term applied to tumors of paraganglia regardless of the location. In rare instances, paragangliomas present around and involve the pancreas, thereby mimicking any one of the more common primary pancreatic lesions. Pancreatic paraganglioma is an extremely rare tumor. It grows slowly, so radical resection is recommended to achieve curability with good prognosis. These neoplasms present considerable diagnostic difficulty not only for the clinician and radiologist but also for the pathologist. Here, we report a case of a 55-year-old woman who presented with a left-sided abdominal swelling for 3 months duration, initially having clinical suspicion of an ovarian tumor. The radiological imaging revealed a lesion in the tail of pancreas with a differential diagnosis of pancreatic carcinoma and metastatic tumor. Only after exploratory laparotomy, the diagnosis was made as a rare case of pancreatic paraganglioma on the basis of histological examination and immunohistochemistry.http://www.ijem.in/article.asp?issn=2230-8210;year=2013;volume=17;issue=5;spage=917;epage=919;aulast=BorgohainChromogranin Aimmunohistochemistrypancreasparaganglioma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mondita Borgohain Gayatri Gogoi Dipak Das Manjusha Biswas |
spellingShingle |
Mondita Borgohain Gayatri Gogoi Dipak Das Manjusha Biswas Pancreatic paraganglioma: An extremely rare entity and crucial role of immunohistochemistry for diagnosis Indian Journal of Endocrinology and Metabolism Chromogranin A immunohistochemistry pancreas paraganglioma |
author_facet |
Mondita Borgohain Gayatri Gogoi Dipak Das Manjusha Biswas |
author_sort |
Mondita Borgohain |
title |
Pancreatic paraganglioma: An extremely rare entity and crucial role of immunohistochemistry for diagnosis |
title_short |
Pancreatic paraganglioma: An extremely rare entity and crucial role of immunohistochemistry for diagnosis |
title_full |
Pancreatic paraganglioma: An extremely rare entity and crucial role of immunohistochemistry for diagnosis |
title_fullStr |
Pancreatic paraganglioma: An extremely rare entity and crucial role of immunohistochemistry for diagnosis |
title_full_unstemmed |
Pancreatic paraganglioma: An extremely rare entity and crucial role of immunohistochemistry for diagnosis |
title_sort |
pancreatic paraganglioma: an extremely rare entity and crucial role of immunohistochemistry for diagnosis |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Endocrinology and Metabolism |
issn |
2230-8210 2230-9500 |
publishDate |
2013-01-01 |
description |
Paragangliomas are rare neuroendocrine neoplasms arising in extra-adrenal chromaffin cells of autonomic nervous system and histologically akin to chemodectomas. They are rare, affecting about 1 in 2,000,000 population. It is a generic term applied to tumors of paraganglia regardless of the location. In rare instances, paragangliomas present around and involve the pancreas, thereby mimicking any one of the more common primary pancreatic lesions. Pancreatic paraganglioma is an extremely rare tumor. It grows slowly, so radical resection is recommended to achieve curability with good prognosis. These neoplasms present considerable diagnostic difficulty not only for the clinician and radiologist but also for the pathologist. Here, we report a case of a 55-year-old woman who presented with a left-sided abdominal swelling for 3 months duration, initially having clinical suspicion of an ovarian tumor. The radiological imaging revealed a lesion in the tail of pancreas with a differential diagnosis of pancreatic carcinoma and metastatic tumor. Only after exploratory laparotomy, the diagnosis was made as a rare case of pancreatic paraganglioma on the basis of histological examination and immunohistochemistry. |
topic |
Chromogranin A immunohistochemistry pancreas paraganglioma |
url |
http://www.ijem.in/article.asp?issn=2230-8210;year=2013;volume=17;issue=5;spage=917;epage=919;aulast=Borgohain |
work_keys_str_mv |
AT monditaborgohain pancreaticparagangliomaanextremelyrareentityandcrucialroleofimmunohistochemistryfordiagnosis AT gayatrigogoi pancreaticparagangliomaanextremelyrareentityandcrucialroleofimmunohistochemistryfordiagnosis AT dipakdas pancreaticparagangliomaanextremelyrareentityandcrucialroleofimmunohistochemistryfordiagnosis AT manjushabiswas pancreaticparagangliomaanextremelyrareentityandcrucialroleofimmunohistochemistryfordiagnosis |
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