Data on effect of Sacubitril/valsartan on cardiac Remodelling in diabetic Cardiomyopathy rats

• Main Authors: Jiao Ai, Jing Liu, Mao Liu
• Format: Article
• Language: English
• Published: Elsevier 2021-04-01
• Series: Data in Brief
• Subjects: Diabetic cardiomyopathy; Sacubitril/valsartan; Cardiac remodeling
• Online Access: http://www.sciencedirect.com/science/article/pii/S235234092100247X

Diabetic cardiomyopathy (DCM) is one of the most important causes of death in patients with diabetic mellitus. The effect of sacubitril/valsartan (Sac/Val) on cardiac remodeling in DCM remains unclear. The present raw data were analysed to assess the effect of Sac/Val-on cardiac remodeling and explore the mechanisms of Sac/Val-in protecting the myocardium in DCM rats. The data include the left ventricular/body mass index, IL-6 and TNF-α levels in myocardial tissue, the protein expression levels of phos-p38, Col Ⅰ and Col Ⅲ in myocardial tissue between pre- and post- Sac/Val-treatment in DCM rats. Compared to DCM rats, the degree of fibrosis and the protein expression of phos-p38, Col Ⅰ and Col Ⅲ reduced after the treatment of Sac/Val. These data may provide useful bases for future clinical research concerning the application of Sac/Val-in patients with DCM.