Identification of Genetic Interaction with Risk Factors Using a Time-To-Event Model

• Main Authors: Mariza de Andrade, Sebastian M. Armasu, Bryan M. McCauley, Tanya M. Petterson, John A. Heit
• Format: Article
• Language: English
• Published: MDPI AG 2017-10-01
• Series: International Journal of Environmental Research and Public Health
• Subjects: genome-wide association study; genetic variation; pregnancy complications; risk factors; venous thromboembolism
• Online Access: https://www.mdpi.com/1660-4601/14/10/1228

Background: Certain diseases can occur with and without a trigger. We use Venous Thromboembolism (VTE) as our example to identify genetic interaction with pregnancy in women with VTE during pre- or postpartum. Pregnancy is one of the major risk factors for VTE as it accounts for 10% of maternal deaths. Methods: We performed a whole genome association analysis using the Cox Proportional Hazard (CoxPH) model adjusted for covariates to identify genetic variants associated with the time-to-event of VTE related to pre- or postpartum during the childbearing age of 18–45 years using a case-only design in a cohort of women with VTE. Women with a VTE event after 45 years of age were censored and contributed only follow-up time. Results: We identified two intragenic single nucleotide polymorphisms (SNPs) at genome-wide significance in the PURB gene located on chromosome 7, and two additional intragenic SNPs, one in the LINGO2 gene on chromosome 9 and one in RDXP2 on chromosome X. Conclusions: We showed that the time-to-event model is a useful approach for identifying potential hazard-modification of the genetic variants when the event of interest (VTE) occurs due to a risk factor (pre- or post-partum).