How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins

How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins

Four inflammatory diseases are strongly associated with Major Histocompatibility Complex class I (MHC-I) molecules: birdshot chorioretinopathy (HLA-A*29:02), ankylosing spondylitis (HLA-B*27), Behçet's disease (HLA-B*51), and psoriasis (HLA-C*06:02). The endoplasmic reticulum aminopeptidases (E...

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Bibliographic Details
Main Author: José A. López de Castro
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
MHC
inflammatory diseases
ERAP
antigen processing
ankylosing spondylitis
uveitis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02463/full

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