Effect of selectively introducing arginine and D-amino acids on the antimicrobial activity and salt sensitivity in analogs of human beta-defensins.
We have examined the antimicrobial activity of C-terminal analogs of human β-defensins HBD-1 and-3 wherein lysines have been selectively replaced by L- and D-arginines and L-isoleucine substituted with its D-enantiomer. The analogs exhibited antibacterial and antifungal activities. Physiological con...
Main Authors: | Sudar Olli, Nandini Rangaraj, Ramakrishnan Nagaraj |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3785448?pdf=render |
Similar Items
-
Human β-defensin 4 with non-native disulfide bridges exhibit antimicrobial activity.
by: Himanshu Sharma, et al.
Published: (2015-01-01) -
Design and activity of a cyclic mini-β-defensin analog: a novel antimicrobial tool
by: Scudiero O, et al.
Published: (2015-10-01) -
Antimicrobial characterization of site-directed mutagenesis of porcine beta defensin 2.
by: Xian-xian Huang, et al.
Published: (2015-01-01) -
Expression and antimicrobial function of beta-defensin 1 in the lower urinary tract.
by: Brian Becknell, et al.
Published: (2013-01-01) -
Analyses of murine beta defensins and defensin inspired peptides
by: Taylor, Karen
Published: (2007)