Obesity Accelerates Age Defects in Mouse and Human B Cells
Obesity, similar to aging, is associated with chronic low-grade systemic inflammation, known as inflammaging, and represents a significantly higher risk for developing chronic diseases typical of old age. Immune cells are recruited to the obese adipose tissue (AT) by chemotactic molecules secreted b...
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doaj-a55b5c06edfb4cdea17d99ce10380e402020-11-25T03:37:37ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-09-011110.3389/fimmu.2020.02060578462Obesity Accelerates Age Defects in Mouse and Human B CellsDaniela Frasca0Daniela Frasca1Bonnie B. Blomberg2Bonnie B. Blomberg3Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United StatesSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, United StatesDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United StatesSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, United StatesObesity, similar to aging, is associated with chronic low-grade systemic inflammation, known as inflammaging, and represents a significantly higher risk for developing chronic diseases typical of old age. Immune cells are recruited to the obese adipose tissue (AT) by chemotactic molecules secreted by non-immune and immune cells in the AT, both contributing to the release of several pro-inflammatory mediators that fuel local and systemic inflammation, to the refractory response of immune cells to further in vivo and in vitro stimulation and to the induction of autoimmune B cells with potentially pathogenic repertoires. In terms of molecular mechanisms involved, leptin, an adipokine secreted primarily by adipocytes, has been proposed to be involved in the reduced generation of protective antibodies, and in the increased generation of autoimmune antibodies, further supporting the concept that obesity accelerates age defects. Leptin has also been shown to induce intrinsic B cell inflammation and B cell immunosenescence. The results presented in this review highlight the importance of weight reduction programs to improve immunity and reduce the risk for developing chronic diseases in obese and older individuals.https://www.frontiersin.org/article/10.3389/fimmu.2020.02060/fullagingobesityB cellsinflammationantibody responses |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Daniela Frasca Daniela Frasca Bonnie B. Blomberg Bonnie B. Blomberg |
spellingShingle |
Daniela Frasca Daniela Frasca Bonnie B. Blomberg Bonnie B. Blomberg Obesity Accelerates Age Defects in Mouse and Human B Cells Frontiers in Immunology aging obesity B cells inflammation antibody responses |
author_facet |
Daniela Frasca Daniela Frasca Bonnie B. Blomberg Bonnie B. Blomberg |
author_sort |
Daniela Frasca |
title |
Obesity Accelerates Age Defects in Mouse and Human B Cells |
title_short |
Obesity Accelerates Age Defects in Mouse and Human B Cells |
title_full |
Obesity Accelerates Age Defects in Mouse and Human B Cells |
title_fullStr |
Obesity Accelerates Age Defects in Mouse and Human B Cells |
title_full_unstemmed |
Obesity Accelerates Age Defects in Mouse and Human B Cells |
title_sort |
obesity accelerates age defects in mouse and human b cells |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2020-09-01 |
description |
Obesity, similar to aging, is associated with chronic low-grade systemic inflammation, known as inflammaging, and represents a significantly higher risk for developing chronic diseases typical of old age. Immune cells are recruited to the obese adipose tissue (AT) by chemotactic molecules secreted by non-immune and immune cells in the AT, both contributing to the release of several pro-inflammatory mediators that fuel local and systemic inflammation, to the refractory response of immune cells to further in vivo and in vitro stimulation and to the induction of autoimmune B cells with potentially pathogenic repertoires. In terms of molecular mechanisms involved, leptin, an adipokine secreted primarily by adipocytes, has been proposed to be involved in the reduced generation of protective antibodies, and in the increased generation of autoimmune antibodies, further supporting the concept that obesity accelerates age defects. Leptin has also been shown to induce intrinsic B cell inflammation and B cell immunosenescence. The results presented in this review highlight the importance of weight reduction programs to improve immunity and reduce the risk for developing chronic diseases in obese and older individuals. |
topic |
aging obesity B cells inflammation antibody responses |
url |
https://www.frontiersin.org/article/10.3389/fimmu.2020.02060/full |
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