Solving the Telomere Replication Problem

Telomeres are complex nucleoprotein structures that protect the extremities of linear chromosomes. Telomere replication is a major challenge because many obstacles to the progression of the replication fork are concentrated at the ends of the chromosomes. This is known as the telomere replication pr...

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Main Authors:	Laetitia Maestroni, Samah Matmati, Stéphane Coulon
Format:	Article
Language:	English
Published:	MDPI AG 2017-01-01
Series:	Genes
Subjects:	Telomere Telomere replication G‐quadruplex T‐loop TERRA
Online Access:	http://www.mdpi.com/2073-4425/8/2/55

id	doaj-a55bbb22957a4d578da79e7e3e744abb
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spelling	doaj-a55bbb22957a4d578da79e7e3e744abb2020-11-24T21:01:39ZengMDPI AGGenes2073-44252017-01-01825510.3390/genes8020055genes8020055Solving the Telomere Replication ProblemLaetitia Maestroni0Samah Matmati1Stéphane Coulon2Aix Marseille Univ, CNRS, INSERM, Institut Paoli‐Calmettes, CRCM, Equipe labélisée Ligue Contre le Cancer, 13273 Marseille, FranceAix Marseille Univ, CNRS, INSERM, Institut Paoli‐Calmettes, CRCM, Equipe labélisée Ligue Contre le Cancer, 13273 Marseille, FranceAix Marseille Univ, CNRS, INSERM, Institut Paoli‐Calmettes, CRCM, Equipe labélisée Ligue Contre le Cancer, 13273 Marseille, FranceTelomeres are complex nucleoprotein structures that protect the extremities of linear chromosomes. Telomere replication is a major challenge because many obstacles to the progression of the replication fork are concentrated at the ends of the chromosomes. This is known as the telomere replication problem. In this article, different and new aspects of telomere replication, that can threaten the integrity of telomeres, will be reviewed. In particular, we will focus on the functions of shelterin and the replisome for the preservation of telomere integrityhttp://www.mdpi.com/2073-4425/8/2/55TelomereTelomere replicationG‐quadruplexT‐loopTERRA
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Laetitia Maestroni Samah Matmati Stéphane Coulon
spellingShingle	Laetitia Maestroni Samah Matmati Stéphane Coulon Solving the Telomere Replication Problem Genes Telomere Telomere replication G‐quadruplex T‐loop TERRA
author_facet	Laetitia Maestroni Samah Matmati Stéphane Coulon
author_sort	Laetitia Maestroni
title	Solving the Telomere Replication Problem
title_short	Solving the Telomere Replication Problem
title_full	Solving the Telomere Replication Problem
title_fullStr	Solving the Telomere Replication Problem
title_full_unstemmed	Solving the Telomere Replication Problem
title_sort	solving the telomere replication problem
publisher	MDPI AG
series	Genes
issn	2073-4425
publishDate	2017-01-01
description	Telomeres are complex nucleoprotein structures that protect the extremities of linear chromosomes. Telomere replication is a major challenge because many obstacles to the progression of the replication fork are concentrated at the ends of the chromosomes. This is known as the telomere replication problem. In this article, different and new aspects of telomere replication, that can threaten the integrity of telomeres, will be reviewed. In particular, we will focus on the functions of shelterin and the replisome for the preservation of telomere integrity
topic	Telomere Telomere replication G‐quadruplex T‐loop TERRA
url	http://www.mdpi.com/2073-4425/8/2/55
work_keys_str_mv	AT laetitiamaestroni solvingthetelomerereplicationproblem AT samahmatmati solvingthetelomerereplicationproblem AT stephanecoulon solvingthetelomerereplicationproblem
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Solving the Telomere Replication Problem

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