Molecular Signatures of <i>JMJD10/</i>MINA53 in Gastric Cancer
The <i>JMJD10</i> gene and its encoded protein MYC-induced nuclear antigen (MINA53) are associated with multiple cancers. Besides having both an oncogenic and tumor suppressor function, the intricate role of <i>JMJD10</i> in cancer is complex as it depends on the cancer type....
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doaj-a5637842c9a74c71b58d2b10e67f71cb2020-11-25T03:52:20ZengMDPI AGCancers2072-66942020-05-01121141114110.3390/cancers12051141Molecular Signatures of <i>JMJD10/</i>MINA53 in Gastric CancerNur Aziz0Yo Han Hong1Minkyeong Jo2Jin Kyeong Kim3Kyung-Hee Kim4Hassan Ashktorab5Duane T. Smoot6Hoon Hur7Byong Chul Yoo8and Jae Youl Cho9Department of Integrative Biotechnology, Sungkyunkwan University, and Biomedical Institute for Convergence at SKKU (BICS), Suwon 16419, KoreaDepartment of Integrative Biotechnology, Sungkyunkwan University, and Biomedical Institute for Convergence at SKKU (BICS), Suwon 16419, KoreaDepartment of Integrative Biotechnology, Sungkyunkwan University, and Biomedical Institute for Convergence at SKKU (BICS), Suwon 16419, KoreaDepartment of Integrative Biotechnology, Sungkyunkwan University, and Biomedical Institute for Convergence at SKKU (BICS), Suwon 16419, KoreaProteomic Analysis Team, Research Institute, National Cancer Center, Goyang 10408, KoreaDepartment of Medicine, Howard University, Washington, DC 20060, USADepartment of Medicine, Meharry Medical Center, Nashville, TN 37208, USADepartment of Surgery, Ajou University School of Medicine, and Department of Biomedical Sciences, Ajou University Graduate School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do 16499, KoreaDivision of Translational Science, Research Institute, National Cancer Center, Goyang 10408, KoreaDepartment of Integrative Biotechnology, Sungkyunkwan University, and Biomedical Institute for Convergence at SKKU (BICS), Suwon 16419, KoreaThe <i>JMJD10</i> gene and its encoded protein MYC-induced nuclear antigen (MINA53) are associated with multiple cancers. Besides having both an oncogenic and tumor suppressor function, the intricate role of <i>JMJD10</i> in cancer is complex as it depends on the cancer type. In particular, the functional role of <i>JMJD10</i>/MINA53 in gastric cancer has been poorly understood. In this study, we have unraveled the molecular signatures and functional roles of <i>JMJD10</i>/MINA53 in gastric cancer by multiple approaches, i.e., multi-omics bioinformatics study, analysis of human gastric cancer tissues, and studies in vitro using knockdown or overexpression strategies in gastric cancer cell lines. The results indicated that the <i>JMJD10</i> gene and MINA53 protein are commonly overexpressed in cancer patients. JMJD10/MINA53 is involved in the regulation of proliferation and survival of gastric cancer by controlling cell cycle gene expression. These processes are highly associated with MINA53 enzymatic activity in the regulation of H3K9me3 methylation status and controlling activation of AP-1 signaling pathways. This highlights the oncogenic role of <i>JMJD10</i>/MINA53 in gastric cancer and opens the opportunity to develop therapeutic targeting of <i>JMJD10</i>/MINA53 in gastric cancer.https://www.mdpi.com/2072-6694/12/5/1141JMJD10/MINA53gastric cancerhistone demethylaseKDM |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nur Aziz Yo Han Hong Minkyeong Jo Jin Kyeong Kim Kyung-Hee Kim Hassan Ashktorab Duane T. Smoot Hoon Hur Byong Chul Yoo and Jae Youl Cho |
spellingShingle |
Nur Aziz Yo Han Hong Minkyeong Jo Jin Kyeong Kim Kyung-Hee Kim Hassan Ashktorab Duane T. Smoot Hoon Hur Byong Chul Yoo and Jae Youl Cho Molecular Signatures of <i>JMJD10/</i>MINA53 in Gastric Cancer Cancers JMJD10/MINA53 gastric cancer histone demethylase KDM |
author_facet |
Nur Aziz Yo Han Hong Minkyeong Jo Jin Kyeong Kim Kyung-Hee Kim Hassan Ashktorab Duane T. Smoot Hoon Hur Byong Chul Yoo and Jae Youl Cho |
author_sort |
Nur Aziz |
title |
Molecular Signatures of <i>JMJD10/</i>MINA53 in Gastric Cancer |
title_short |
Molecular Signatures of <i>JMJD10/</i>MINA53 in Gastric Cancer |
title_full |
Molecular Signatures of <i>JMJD10/</i>MINA53 in Gastric Cancer |
title_fullStr |
Molecular Signatures of <i>JMJD10/</i>MINA53 in Gastric Cancer |
title_full_unstemmed |
Molecular Signatures of <i>JMJD10/</i>MINA53 in Gastric Cancer |
title_sort |
molecular signatures of <i>jmjd10/</i>mina53 in gastric cancer |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2020-05-01 |
description |
The <i>JMJD10</i> gene and its encoded protein MYC-induced nuclear antigen (MINA53) are associated with multiple cancers. Besides having both an oncogenic and tumor suppressor function, the intricate role of <i>JMJD10</i> in cancer is complex as it depends on the cancer type. In particular, the functional role of <i>JMJD10</i>/MINA53 in gastric cancer has been poorly understood. In this study, we have unraveled the molecular signatures and functional roles of <i>JMJD10</i>/MINA53 in gastric cancer by multiple approaches, i.e., multi-omics bioinformatics study, analysis of human gastric cancer tissues, and studies in vitro using knockdown or overexpression strategies in gastric cancer cell lines. The results indicated that the <i>JMJD10</i> gene and MINA53 protein are commonly overexpressed in cancer patients. JMJD10/MINA53 is involved in the regulation of proliferation and survival of gastric cancer by controlling cell cycle gene expression. These processes are highly associated with MINA53 enzymatic activity in the regulation of H3K9me3 methylation status and controlling activation of AP-1 signaling pathways. This highlights the oncogenic role of <i>JMJD10</i>/MINA53 in gastric cancer and opens the opportunity to develop therapeutic targeting of <i>JMJD10</i>/MINA53 in gastric cancer. |
topic |
JMJD10/MINA53 gastric cancer histone demethylase KDM |
url |
https://www.mdpi.com/2072-6694/12/5/1141 |
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