Heat Shock Proteins in Alzheimer’s Disease: Role and Targeting
Among diseases whose cure is still far from being discovered, Alzheimer’s disease (AD) has been recognized as a crucial medical and social problem. A major issue in AD research is represented by the complexity of involved biochemical pathways, including the nature of protein misfolding, wh...
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doaj-a584c890419f4aa79c16cc02da9bd2352020-11-25T02:28:09ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-09-01199260310.3390/ijms19092603ijms19092603Heat Shock Proteins in Alzheimer’s Disease: Role and TargetingClaudia Campanella0Andrea Pace1Celeste Caruso Bavisotto2Paola Marzullo3Antonella Marino Gammazza4Silvestre Buscemi5Antonio Palumbo Piccionello6Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche (BIONEC), Università degli Studi di Palermo, Via del Vespro 129, 90127 Palermo, ItalyDipartimento di Scienze e Tecnologie Biologiche, Università degli Studi di Palermo, Chimiche e Farmaceutiche (STEBICEF), Viale delle scienze Ed.17, 90128 Palermo, ItalyDipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche (BIONEC), Università degli Studi di Palermo, Via del Vespro 129, 90127 Palermo, ItalyDipartimento di Scienze e Tecnologie Biologiche, Università degli Studi di Palermo, Chimiche e Farmaceutiche (STEBICEF), Viale delle scienze Ed.17, 90128 Palermo, ItalyDipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche (BIONEC), Università degli Studi di Palermo, Via del Vespro 129, 90127 Palermo, ItalyDipartimento di Scienze e Tecnologie Biologiche, Università degli Studi di Palermo, Chimiche e Farmaceutiche (STEBICEF), Viale delle scienze Ed.17, 90128 Palermo, ItalyDipartimento di Scienze e Tecnologie Biologiche, Università degli Studi di Palermo, Chimiche e Farmaceutiche (STEBICEF), Viale delle scienze Ed.17, 90128 Palermo, ItalyAmong diseases whose cure is still far from being discovered, Alzheimer’s disease (AD) has been recognized as a crucial medical and social problem. A major issue in AD research is represented by the complexity of involved biochemical pathways, including the nature of protein misfolding, which results in the production of toxic species. Considering the involvement of (mis)folding processes in AD aetiology, targeting molecular chaperones represents a promising therapeutic perspective. This review analyses the connection between AD and molecular chaperones, with particular attention toward the most important heat shock proteins (HSPs) as representative components of the human chaperome: Hsp60, Hsp70 and Hsp90. The role of these proteins in AD is highlighted from a biological point of view. Pharmacological targeting of such HSPs with inhibitors or regulators is also discussed.http://www.mdpi.com/1422-0067/19/9/2603heat shock proteinschaperonesAlzheimer’s diseaseamyloid peptideprotein TauHsp60Hsp70Hsp90 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Claudia Campanella Andrea Pace Celeste Caruso Bavisotto Paola Marzullo Antonella Marino Gammazza Silvestre Buscemi Antonio Palumbo Piccionello |
spellingShingle |
Claudia Campanella Andrea Pace Celeste Caruso Bavisotto Paola Marzullo Antonella Marino Gammazza Silvestre Buscemi Antonio Palumbo Piccionello Heat Shock Proteins in Alzheimer’s Disease: Role and Targeting International Journal of Molecular Sciences heat shock proteins chaperones Alzheimer’s disease amyloid peptide protein Tau Hsp60 Hsp70 Hsp90 |
author_facet |
Claudia Campanella Andrea Pace Celeste Caruso Bavisotto Paola Marzullo Antonella Marino Gammazza Silvestre Buscemi Antonio Palumbo Piccionello |
author_sort |
Claudia Campanella |
title |
Heat Shock Proteins in Alzheimer’s Disease: Role and Targeting |
title_short |
Heat Shock Proteins in Alzheimer’s Disease: Role and Targeting |
title_full |
Heat Shock Proteins in Alzheimer’s Disease: Role and Targeting |
title_fullStr |
Heat Shock Proteins in Alzheimer’s Disease: Role and Targeting |
title_full_unstemmed |
Heat Shock Proteins in Alzheimer’s Disease: Role and Targeting |
title_sort |
heat shock proteins in alzheimer’s disease: role and targeting |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2018-09-01 |
description |
Among diseases whose cure is still far from being discovered, Alzheimer’s disease (AD) has been recognized as a crucial medical and social problem. A major issue in AD research is represented by the complexity of involved biochemical pathways, including the nature of protein misfolding, which results in the production of toxic species. Considering the involvement of (mis)folding processes in AD aetiology, targeting molecular chaperones represents a promising therapeutic perspective. This review analyses the connection between AD and molecular chaperones, with particular attention toward the most important heat shock proteins (HSPs) as representative components of the human chaperome: Hsp60, Hsp70 and Hsp90. The role of these proteins in AD is highlighted from a biological point of view. Pharmacological targeting of such HSPs with inhibitors or regulators is also discussed. |
topic |
heat shock proteins chaperones Alzheimer’s disease amyloid peptide protein Tau Hsp60 Hsp70 Hsp90 |
url |
http://www.mdpi.com/1422-0067/19/9/2603 |
work_keys_str_mv |
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1724839959530045440 |