Robust innate responses to SARS-CoV-2 in children resolve faster than in adults without compromising adaptive immunity

Robust innate responses to SARS-CoV-2 in children resolve faster than in adults without compromising adaptive immunity

Summary: SARS-CoV-2 infection in children is less severe than it is in adults. We perform a longitudinal analysis of the early innate responses in children and adults with mild infection within household clusters. Children display fewer symptoms than adults do, despite similar initial viral load, an...

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Bibliographic Details
Main Authors: Maria Vono, Angela Huttner, Sylvain Lemeille, Paola Martinez-Murillo, Benjamin Meyer, Stephanie Baggio, Shilpee Sharma, Anais Thiriard, Arnaud Marchant, Gert-Jan Godeke, Chantal Reusken, Catia Alvarez, Francisco Perez-Rodriguez, Isabella Eckerle, Laurent Kaiser, Natasha Loevy, Christiane S. Eberhardt, Geraldine Blanchard-Rohner, Claire-Anne Siegrist, Arnaud M. Didierlaurent
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Cell Reports
Subjects:
SARS-CoV-2
COVID-19
children
innate responses
interferon
B cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721012274

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http://www.sciencedirect.com/science/article/pii/S2211124721012274

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