Associations of maternal arsenic exposure with adult fasting glucose and insulin resistance in the Strong Heart Study and Strong Heart Family Study
Experimental and prospective epidemiologic evidence suggest that arsenic exposure has diabetogenic effects. However, little is known about how family exposure to arsenic may affect risk for type 2 diabetes (T2D)-related outcomes in adulthood. We evaluated the association of both maternal and offspri...
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Elsevier
2020-04-01
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Series: | Environment International |
Online Access: | http://www.sciencedirect.com/science/article/pii/S016041201932611X |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Naomi E. Tinkelman Miranda Jones Spratlen Arce Domingo-Relloso Maria Tellez-Plaza Maria Grau-Perez Kevin A. Francesconi Walter Goessler Barbara V. Howard Jean MacCluer Kari E. North Jason G. Umans Pam Factor-Litvak Shelley A. Cole Ana Navas-Acien |
spellingShingle |
Naomi E. Tinkelman Miranda Jones Spratlen Arce Domingo-Relloso Maria Tellez-Plaza Maria Grau-Perez Kevin A. Francesconi Walter Goessler Barbara V. Howard Jean MacCluer Kari E. North Jason G. Umans Pam Factor-Litvak Shelley A. Cole Ana Navas-Acien Associations of maternal arsenic exposure with adult fasting glucose and insulin resistance in the Strong Heart Study and Strong Heart Family Study Environment International |
author_facet |
Naomi E. Tinkelman Miranda Jones Spratlen Arce Domingo-Relloso Maria Tellez-Plaza Maria Grau-Perez Kevin A. Francesconi Walter Goessler Barbara V. Howard Jean MacCluer Kari E. North Jason G. Umans Pam Factor-Litvak Shelley A. Cole Ana Navas-Acien |
author_sort |
Naomi E. Tinkelman |
title |
Associations of maternal arsenic exposure with adult fasting glucose and insulin resistance in the Strong Heart Study and Strong Heart Family Study |
title_short |
Associations of maternal arsenic exposure with adult fasting glucose and insulin resistance in the Strong Heart Study and Strong Heart Family Study |
title_full |
Associations of maternal arsenic exposure with adult fasting glucose and insulin resistance in the Strong Heart Study and Strong Heart Family Study |
title_fullStr |
Associations of maternal arsenic exposure with adult fasting glucose and insulin resistance in the Strong Heart Study and Strong Heart Family Study |
title_full_unstemmed |
Associations of maternal arsenic exposure with adult fasting glucose and insulin resistance in the Strong Heart Study and Strong Heart Family Study |
title_sort |
associations of maternal arsenic exposure with adult fasting glucose and insulin resistance in the strong heart study and strong heart family study |
publisher |
Elsevier |
series |
Environment International |
issn |
0160-4120 |
publishDate |
2020-04-01 |
description |
Experimental and prospective epidemiologic evidence suggest that arsenic exposure has diabetogenic effects. However, little is known about how family exposure to arsenic may affect risk for type 2 diabetes (T2D)-related outcomes in adulthood. We evaluated the association of both maternal and offspring arsenic exposure with fasting glucose and incident T2D in 466 participants of the Strong Heart Family Study. Total arsenic (ΣAs) exposure was calculated as the sum of inorganic arsenic (iAs) and methylated (MMA, DMA) arsenic species in maternal and offspring baseline urine. Median maternal ΣAs at baseline (1989–91) was 7.6 µg/g creatinine, while median offspring ΣAs at baseline (2001–03) was 4.5 µg/g creatinine. Median offspring glucose in 2006–2009 was 94 mg/dL, and 79 participants developed T2D. The fully adjusted mean difference (95% CI) for offspring glucose was 4.40 (−3.46, 12.26) mg/dL per IQR increase in maternal ΣAs vs. 2.72 (−4.91 to 10.34) mg/dL per IQR increase in offspring ΣAs. The fully adjusted odds ratio (95%CI) of incident T2D was 1.35 (1.07, 1.69) for an IQR increase in maternal ΣAs and 1.15 (0.92, 1.43) for offspring ΣAs. The association of maternal ΣAs with T2D outcomes were attenuated with adjustment for offspring adiposity markers. Familial exposure to arsenic, as measured in mothers 15–20 years before offspring follow-up, is associated with increased odds of offspring T2D. More research is needed to confirm findings and better understand the importance of family exposure to arsenic in adult-onset diabetes. Keywords: American Indians, Arsenic, Indigenous populations, Fasting glucose, Insulin resistance, Prospective cohort studies, Prenatal exposures |
url |
http://www.sciencedirect.com/science/article/pii/S016041201932611X |
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doaj-a5a1fa6c3cb94af785bf504eca98b19c2020-11-25T00:37:32ZengElsevierEnvironment International0160-41202020-04-01137Associations of maternal arsenic exposure with adult fasting glucose and insulin resistance in the Strong Heart Study and Strong Heart Family StudyNaomi E. Tinkelman0Miranda Jones Spratlen1Arce Domingo-Relloso2Maria Tellez-Plaza3Maria Grau-Perez4Kevin A. Francesconi5Walter Goessler6Barbara V. Howard7Jean MacCluer8Kari E. North9Jason G. Umans10Pam Factor-Litvak11Shelley A. Cole12Ana Navas-Acien13Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA; Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA; Corresponding authors at: Columbia University Mailman School of Public Health, 722 W. 168th Street, Room 1105, New York, NY 10032, USA.Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USADepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USANational Center of Epidemiology, Institute of Health Carlos III, Madrid, SpainDepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USAInstitute of Chemistry, University of Graz, Graz, AustriaInstitute of Chemistry, University of Graz, Graz, AustriaGeorgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC, USA; MedStar Health Research Institute, Hyattsville, MD, USAPopulation Health Program, Texas Biomedical Research Institute, San Antonio, TX, USADepartment of Epidemiology, University of North Carolina Gillings School of Public Health, Chapel Hill, NC, USAGeorgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC, USA; MedStar Health Research Institute, Hyattsville, MD, USADepartment of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USADepartment of Epidemiology, University of North Carolina Gillings School of Public Health, Chapel Hill, NC, USADepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA; Corresponding authors at: Columbia University Mailman School of Public Health, 722 W. 168th Street, Room 1105, New York, NY 10032, USA.Experimental and prospective epidemiologic evidence suggest that arsenic exposure has diabetogenic effects. However, little is known about how family exposure to arsenic may affect risk for type 2 diabetes (T2D)-related outcomes in adulthood. We evaluated the association of both maternal and offspring arsenic exposure with fasting glucose and incident T2D in 466 participants of the Strong Heart Family Study. Total arsenic (ΣAs) exposure was calculated as the sum of inorganic arsenic (iAs) and methylated (MMA, DMA) arsenic species in maternal and offspring baseline urine. Median maternal ΣAs at baseline (1989–91) was 7.6 µg/g creatinine, while median offspring ΣAs at baseline (2001–03) was 4.5 µg/g creatinine. Median offspring glucose in 2006–2009 was 94 mg/dL, and 79 participants developed T2D. The fully adjusted mean difference (95% CI) for offspring glucose was 4.40 (−3.46, 12.26) mg/dL per IQR increase in maternal ΣAs vs. 2.72 (−4.91 to 10.34) mg/dL per IQR increase in offspring ΣAs. The fully adjusted odds ratio (95%CI) of incident T2D was 1.35 (1.07, 1.69) for an IQR increase in maternal ΣAs and 1.15 (0.92, 1.43) for offspring ΣAs. The association of maternal ΣAs with T2D outcomes were attenuated with adjustment for offspring adiposity markers. Familial exposure to arsenic, as measured in mothers 15–20 years before offspring follow-up, is associated with increased odds of offspring T2D. More research is needed to confirm findings and better understand the importance of family exposure to arsenic in adult-onset diabetes. Keywords: American Indians, Arsenic, Indigenous populations, Fasting glucose, Insulin resistance, Prospective cohort studies, Prenatal exposureshttp://www.sciencedirect.com/science/article/pii/S016041201932611X |