A common SNP in the UNG gene decreases ovarian cancer risk in BRCA2 mutation carriers

A common SNP in the UNG gene decreases ovarian cancer risk in BRCA2 mutation carriers

Single nucleotide polymorphisms (SNPs) in DNA glycosylase genes involved in the base excision repair (BER) pathway can modify breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. We previously found that SNP rs34259 in the uracil‐DNA glycosylase gene (UNG) might decrease ovarian canc...

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Bibliographic Details
Main Authors: Juan Miguel Baquero, Carlos Benítez‐Buelga, Victoria Fernández, Miguel Urioste, Jose Luis García‐Giménez, Rosario Perona, the CIMBA Consortium, Javier Benítez, Ana Osorio
Format: Article
Language:English
Published: Wiley 2019-05-01
Series:Molecular Oncology
Subjects:
BRCA2
cancer risk modifier
DNA damage
oxidative stress susceptibility
telomere damage
uracil‐DNA glycosylase
Online Access:https://doi.org/10.1002/1878-0261.12470

Internet

https://doi.org/10.1002/1878-0261.12470

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