Epstein-Barr Virus LMP1 Promotes Syntenin-1- and Hrs-Induced Extracellular Vesicle Formation for Its Own Secretion To Increase Cell Proliferation and Migration

Epstein-Barr Virus LMP1 Promotes Syntenin-1- and Hrs-Induced Extracellular Vesicle Formation for Its Own Secretion To Increase Cell Proliferation and Migration

LMP1 is a notable viral protein that contributes to the modification of EV content and tumor microenvironment remodeling. LMP1-modified EVs enhance tumor proliferation, migration, and invasion potential and promote radioresistance. Currently, the mechanisms surrounding LMP1 incorporation into the ho...

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Bibliographic Details
Main Authors: Dingani Nkosi, Li Sun, Leanne C. Duke, Nilkumar Patel, Sunil K. Surapaneni, Mandip Singh, David G. Meckes
Format: Article
Language:English
Published: American Society for Microbiology 2020-06-01
Series:mBio
Subjects:
exosomes
lmp1
syntenin-1
epstein-barr virus
trafficking
extracellular vesicles
herpesvirus
escrt
microvesicles
oncosomes
Online Access:https://doi.org/10.1128/mBio.00589-20

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