Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination

Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination

Targeting the glycolytic PFKFB3 enzyme is being studied as a therapeutic strategy against cancer. Here the authors identify PFKFB3 as being involved in homologous recombination (HR) repair of DNA double strand breaks (DSBs) and present a PFKFB3 inhibitor.

Bibliographic Details
Main Authors: Nina M. S. Gustafsson, Katarina Färnegårdh, Nadilly Bonagas, Anna Huguet Ninou, Petra Groth, Elisee Wiita, Mattias Jönsson, Kenth Hallberg, Jemina Lehto, Rosa Pennisi, Jessica Martinsson, Carina Norström, Jessica Hollers, Johan Schultz, Martin Andersson, Natalia Markova, Petra Marttila, Baek Kim, Martin Norin, Thomas Olin, Thomas Helleday
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06287-x
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spelling doaj-a5be37faa19d4d1fbbb9c428f096c5242021-05-11T10:04:25ZengNature Publishing GroupNature Communications2041-17232018-09-019111610.1038/s41467-018-06287-xTargeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombinationNina M. S. Gustafsson0Katarina Färnegårdh1Nadilly Bonagas2Anna Huguet Ninou3Petra Groth4Elisee Wiita5Mattias Jönsson6Kenth Hallberg7Jemina Lehto8Rosa Pennisi9Jessica Martinsson10Carina Norström11Jessica Hollers12Johan Schultz13Martin Andersson14Natalia Markova15Petra Marttila16Baek Kim17Martin Norin18Thomas Olin19Thomas Helleday20Science for Life Laboratory, Department of Oncology and Pathology, Karolinska InstitutetKancera AB, Karolinska Science ParkScience for Life Laboratory, Department of Oncology and Pathology, Karolinska InstitutetScience for Life Laboratory, Department of Oncology and Pathology, Karolinska InstitutetScience for Life Laboratory, Department of Oncology and Pathology, Karolinska InstitutetScience for Life Laboratory, Department of Oncology and Pathology, Karolinska InstitutetKancera AB, Karolinska Science ParkSARomics Biostructures ABScience for Life Laboratory, Department of Oncology and Pathology, Karolinska InstitutetDepartment of Sciences, Roma Tre UniversitySprint BioscienceKancera AB, Karolinska Science ParkDepartment of Pediatrics, Emory University School of MedicineKancera AB, Karolinska Science ParkSprint BioscienceMalvern InstrumentsScience for Life Laboratory, Department of Oncology and Pathology, Karolinska InstitutetDepartment of Pediatrics, Emory University School of MedicineKancera AB, Karolinska Science ParkKancera AB, Karolinska Science ParkScience for Life Laboratory, Department of Oncology and Pathology, Karolinska InstitutetTargeting the glycolytic PFKFB3 enzyme is being studied as a therapeutic strategy against cancer. Here the authors identify PFKFB3 as being involved in homologous recombination (HR) repair of DNA double strand breaks (DSBs) and present a PFKFB3 inhibitor.https://doi.org/10.1038/s41467-018-06287-x
collection DOAJ
language English
format Article
sources DOAJ
author Nina M. S. Gustafsson
Katarina Färnegårdh
Nadilly Bonagas
Anna Huguet Ninou
Petra Groth
Elisee Wiita
Mattias Jönsson
Kenth Hallberg
Jemina Lehto
Rosa Pennisi
Jessica Martinsson
Carina Norström
Jessica Hollers
Johan Schultz
Martin Andersson
Natalia Markova
Petra Marttila
Baek Kim
Martin Norin
Thomas Olin
Thomas Helleday
spellingShingle Nina M. S. Gustafsson
Katarina Färnegårdh
Nadilly Bonagas
Anna Huguet Ninou
Petra Groth
Elisee Wiita
Mattias Jönsson
Kenth Hallberg
Jemina Lehto
Rosa Pennisi
Jessica Martinsson
Carina Norström
Jessica Hollers
Johan Schultz
Martin Andersson
Natalia Markova
Petra Marttila
Baek Kim
Martin Norin
Thomas Olin
Thomas Helleday
Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination
Nature Communications
author_facet Nina M. S. Gustafsson
Katarina Färnegårdh
Nadilly Bonagas
Anna Huguet Ninou
Petra Groth
Elisee Wiita
Mattias Jönsson
Kenth Hallberg
Jemina Lehto
Rosa Pennisi
Jessica Martinsson
Carina Norström
Jessica Hollers
Johan Schultz
Martin Andersson
Natalia Markova
Petra Marttila
Baek Kim
Martin Norin
Thomas Olin
Thomas Helleday
author_sort Nina M. S. Gustafsson
title Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination
title_short Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination
title_full Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination
title_fullStr Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination
title_full_unstemmed Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination
title_sort targeting pfkfb3 radiosensitizes cancer cells and suppresses homologous recombination
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-09-01
description Targeting the glycolytic PFKFB3 enzyme is being studied as a therapeutic strategy against cancer. Here the authors identify PFKFB3 as being involved in homologous recombination (HR) repair of DNA double strand breaks (DSBs) and present a PFKFB3 inhibitor.
url https://doi.org/10.1038/s41467-018-06287-x
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