Haemopoietic stem cell transplantation in Systemic lupus erythematosus: a systematic review
Abstract Despite advances in treating Systemic lupus erythematosus (SLE), a proportion of patients continue to face significant morbidity and mortality. Haemopoietic stem cell transplant (HSCT) has been recognized as an option for such patients. We analysed the evidence on efficacy and safety of HSC...
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doaj-a5c36a9c58ab4bdc8875284076034c322020-11-25T03:02:52ZengBMCAllergy, Asthma & Clinical Immunology1710-14922019-09-0115111210.1186/s13223-019-0373-yHaemopoietic stem cell transplantation in Systemic lupus erythematosus: a systematic reviewNipun Lakshitha de Silva0Suranjith L. Seneviratne1Department of Clinical Sciences, Faculty of Medicine, General Sir John Kotelawala Defence UniversityDepartment of Surgery, Faculty of Medicine, University of ColomboAbstract Despite advances in treating Systemic lupus erythematosus (SLE), a proportion of patients continue to face significant morbidity and mortality. Haemopoietic stem cell transplant (HSCT) has been recognized as an option for such patients. We analysed the evidence on efficacy and safety of HSCT in patients with SLE. A database search was done for articles on HSCT in SLE up to July 2017 in PUBMED, Cochrane library, LILACS and clinical trial registration databases to select prospective or retrospective studies with 8 or more patients. Of the 732 search results from the PUBMED, Cochrane and LILACS database search, following duplicate removal, 15 studies were eligible for detailed assessment. Findings of an additional trial were obtained from the clinical trial registration database. Data were extracted on study design, patient characteristics, nature of intervention, outcomes, complications and study quality. Case reports and small case series were summarised without detailed qualitative analysis. Most of the studies showed remission in the majority of patients. Relapse of the original disease increased with longer follow-up. Common adverse effects included: infections and secondary autoimmune disorders. Short follow up period and lack of randomised controlled trials were the main limitations restricting the generalizability of study results. A meta-analysis was not performed due to heterogeneity of studies. Although HSCT is a viable option in SLE, its exact clinical utility needs to be further evaluated in well-designed studies.http://link.springer.com/article/10.1186/s13223-019-0373-ySystemic lupus erythematosusBone marrow transplantHaemopoietic stem cell transplantMorbidityMortality |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nipun Lakshitha de Silva Suranjith L. Seneviratne |
spellingShingle |
Nipun Lakshitha de Silva Suranjith L. Seneviratne Haemopoietic stem cell transplantation in Systemic lupus erythematosus: a systematic review Allergy, Asthma & Clinical Immunology Systemic lupus erythematosus Bone marrow transplant Haemopoietic stem cell transplant Morbidity Mortality |
author_facet |
Nipun Lakshitha de Silva Suranjith L. Seneviratne |
author_sort |
Nipun Lakshitha de Silva |
title |
Haemopoietic stem cell transplantation in Systemic lupus erythematosus: a systematic review |
title_short |
Haemopoietic stem cell transplantation in Systemic lupus erythematosus: a systematic review |
title_full |
Haemopoietic stem cell transplantation in Systemic lupus erythematosus: a systematic review |
title_fullStr |
Haemopoietic stem cell transplantation in Systemic lupus erythematosus: a systematic review |
title_full_unstemmed |
Haemopoietic stem cell transplantation in Systemic lupus erythematosus: a systematic review |
title_sort |
haemopoietic stem cell transplantation in systemic lupus erythematosus: a systematic review |
publisher |
BMC |
series |
Allergy, Asthma & Clinical Immunology |
issn |
1710-1492 |
publishDate |
2019-09-01 |
description |
Abstract Despite advances in treating Systemic lupus erythematosus (SLE), a proportion of patients continue to face significant morbidity and mortality. Haemopoietic stem cell transplant (HSCT) has been recognized as an option for such patients. We analysed the evidence on efficacy and safety of HSCT in patients with SLE. A database search was done for articles on HSCT in SLE up to July 2017 in PUBMED, Cochrane library, LILACS and clinical trial registration databases to select prospective or retrospective studies with 8 or more patients. Of the 732 search results from the PUBMED, Cochrane and LILACS database search, following duplicate removal, 15 studies were eligible for detailed assessment. Findings of an additional trial were obtained from the clinical trial registration database. Data were extracted on study design, patient characteristics, nature of intervention, outcomes, complications and study quality. Case reports and small case series were summarised without detailed qualitative analysis. Most of the studies showed remission in the majority of patients. Relapse of the original disease increased with longer follow-up. Common adverse effects included: infections and secondary autoimmune disorders. Short follow up period and lack of randomised controlled trials were the main limitations restricting the generalizability of study results. A meta-analysis was not performed due to heterogeneity of studies. Although HSCT is a viable option in SLE, its exact clinical utility needs to be further evaluated in well-designed studies. |
topic |
Systemic lupus erythematosus Bone marrow transplant Haemopoietic stem cell transplant Morbidity Mortality |
url |
http://link.springer.com/article/10.1186/s13223-019-0373-y |
work_keys_str_mv |
AT nipunlakshithadesilva haemopoieticstemcelltransplantationinsystemiclupuserythematosusasystematicreview AT suranjithlseneviratne haemopoieticstemcelltransplantationinsystemiclupuserythematosusasystematicreview |
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