T cell responses in respiratory viral infections and chronic obstructive pulmonary disease
Abstract. Respiratory viruses are major human pathogens that cause approximately 200 million pneumonia cases annually and induce various comorbidities with chronic obstructive pulmonary disease (COPD), resulting in significant health concerns and economic burdens. Clinical manifestations in respirat...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer
2021-07-01
|
Series: | Chinese Medical Journal |
Online Access: | http://journals.lww.com/10.1097/CM9.0000000000001388 |
id |
doaj-a5d1785368b148a08b275842cee7e1e8 |
---|---|
record_format |
Article |
spelling |
doaj-a5d1785368b148a08b275842cee7e1e82021-07-26T05:29:08ZengWolters KluwerChinese Medical Journal0366-69992542-56412021-07-01134131522153410.1097/CM9.0000000000001388202107050-00004T cell responses in respiratory viral infections and chronic obstructive pulmonary diseaseShouxiong HuangQuan HeLinfu ZhouPei-Fang WeiAbstract. Respiratory viruses are major human pathogens that cause approximately 200 million pneumonia cases annually and induce various comorbidities with chronic obstructive pulmonary disease (COPD), resulting in significant health concerns and economic burdens. Clinical manifestations in respiratory viral infections and inflammations vary from asymptomatic, mild, to severe, depending on host immune cell responses to pathogens and interactions with airway epithelia. We critically review the activation, effector, and regulation of T cells in respiratory virus infections and chronic inflammations associated with COPD. Crosstalk among T cells, innate immune cells, and airway epithelial cells is discussed as essential parts of pathogenesis and protection in viral infections and COPD. We emphasize the specificity of peptide antigens and the functional heterogeneity of conventional CD4+ and CD8+ T cells to shed some light on potential cellular and molecular candidates for the future development of therapeutics and intervention against respiratory viral infections and inflammations.http://journals.lww.com/10.1097/CM9.0000000000001388 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shouxiong Huang Quan He Linfu Zhou Pei-Fang Wei |
spellingShingle |
Shouxiong Huang Quan He Linfu Zhou Pei-Fang Wei T cell responses in respiratory viral infections and chronic obstructive pulmonary disease Chinese Medical Journal |
author_facet |
Shouxiong Huang Quan He Linfu Zhou Pei-Fang Wei |
author_sort |
Shouxiong Huang |
title |
T cell responses in respiratory viral infections and chronic obstructive pulmonary disease |
title_short |
T cell responses in respiratory viral infections and chronic obstructive pulmonary disease |
title_full |
T cell responses in respiratory viral infections and chronic obstructive pulmonary disease |
title_fullStr |
T cell responses in respiratory viral infections and chronic obstructive pulmonary disease |
title_full_unstemmed |
T cell responses in respiratory viral infections and chronic obstructive pulmonary disease |
title_sort |
t cell responses in respiratory viral infections and chronic obstructive pulmonary disease |
publisher |
Wolters Kluwer |
series |
Chinese Medical Journal |
issn |
0366-6999 2542-5641 |
publishDate |
2021-07-01 |
description |
Abstract. Respiratory viruses are major human pathogens that cause approximately 200 million pneumonia cases annually and induce various comorbidities with chronic obstructive pulmonary disease (COPD), resulting in significant health concerns and economic burdens. Clinical manifestations in respiratory viral infections and inflammations vary from asymptomatic, mild, to severe, depending on host immune cell responses to pathogens and interactions with airway epithelia. We critically review the activation, effector, and regulation of T cells in respiratory virus infections and chronic inflammations associated with COPD. Crosstalk among T cells, innate immune cells, and airway epithelial cells is discussed as essential parts of pathogenesis and protection in viral infections and COPD. We emphasize the specificity of peptide antigens and the functional heterogeneity of conventional CD4+ and CD8+ T cells to shed some light on potential cellular and molecular candidates for the future development of therapeutics and intervention against respiratory viral infections and inflammations. |
url |
http://journals.lww.com/10.1097/CM9.0000000000001388 |
work_keys_str_mv |
AT shouxionghuang tcellresponsesinrespiratoryviralinfectionsandchronicobstructivepulmonarydisease AT quanhe tcellresponsesinrespiratoryviralinfectionsandchronicobstructivepulmonarydisease AT linfuzhou tcellresponsesinrespiratoryviralinfectionsandchronicobstructivepulmonarydisease AT peifangwei tcellresponsesinrespiratoryviralinfectionsandchronicobstructivepulmonarydisease |
_version_ |
1721282353497636864 |