A Cell Line for Detection of Botulinum Neurotoxin Type B

Botulinum neurotoxins (BoNTs) type A and type B are commonly used as biopharmaceutics for neurological diseases, uniquely allowing months-long paralysis of target muscles. Their exquisite neuronal specificity is conferred by a multistep process of binding, internalization, cytosolic escape and cleav...

Full description

Bibliographic Details
Main Authors: Aleksander Rust, Ciara Doran, Rosalyn Hart, Thomas Binz, Paul Stickings, Dorothea Sesardic, Andrew A. Peden, Bazbek Davletov
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00796/full