Annotated compound data for modulators of detergent-solubilised or lipid-reconstituted respiratory type II NADH dehydrogenase activity obtained by compound library screening
The energy-generating membrane protein NADH dehydrogenase (NDH-2), a proposed antibacterial drug target (see “Inhibitors of type II NADH:menaquinone oxidoreductase represent a class of antitubercular drugs” Weinstein et al. 2005 [1]), was screened for modulators of activity in either detergent-solub...
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doaj-a5ddaad1b4324c1fb003165ad7161fbf2020-11-24T20:42:54ZengElsevierData in Brief2352-34092016-03-016275278Annotated compound data for modulators of detergent-solubilised or lipid-reconstituted respiratory type II NADH dehydrogenase activity obtained by compound library screeningElyse A. Dunn0Gregory M. Cook1Adam Heikal2Department of Microbiology and Immunology, University of Otago, Dunedin 9054, New ZealandDepartment of Microbiology and Immunology, University of Otago, Dunedin 9054, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Private Bag 92019, Auckland 1042, New Zealand; Corresponding authors at: Department of Microbiology and Immunology, University of Otago, Dunedin 9054, New Zealand. Tel.: +64 3 471 6464.Department of Microbiology and Immunology, University of Otago, Dunedin 9054, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Private Bag 92019, Auckland 1042, New Zealand; Corresponding authors at: Department of Microbiology and Immunology, University of Otago, Dunedin 9054, New Zealand. Tel.: +64 3 471 6464.The energy-generating membrane protein NADH dehydrogenase (NDH-2), a proposed antibacterial drug target (see “Inhibitors of type II NADH:menaquinone oxidoreductase represent a class of antitubercular drugs” Weinstein et al. 2005 [1]), was screened for modulators of activity in either detergent-solublised or lipid reconstituted (proteolipsome) form. Here we present an annotated list of compounds identified in a small-scale screen against NDH-2. The dataset contains information regarding the libraries screened, the identities of hit compounds and the physicochemical properties governing solubility and permeability. The implications of these data for future antibiotic discovery are discussed in our associated report, “Comparison of lipid and detergent enzyme environments for identifying inhibitors of membrane-bound energy-transducing proteins” [2].http://www.sciencedirect.com/science/article/pii/S2352340915003856 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Elyse A. Dunn Gregory M. Cook Adam Heikal |
spellingShingle |
Elyse A. Dunn Gregory M. Cook Adam Heikal Annotated compound data for modulators of detergent-solubilised or lipid-reconstituted respiratory type II NADH dehydrogenase activity obtained by compound library screening Data in Brief |
author_facet |
Elyse A. Dunn Gregory M. Cook Adam Heikal |
author_sort |
Elyse A. Dunn |
title |
Annotated compound data for modulators of detergent-solubilised or lipid-reconstituted respiratory type II NADH dehydrogenase activity obtained by compound library screening |
title_short |
Annotated compound data for modulators of detergent-solubilised or lipid-reconstituted respiratory type II NADH dehydrogenase activity obtained by compound library screening |
title_full |
Annotated compound data for modulators of detergent-solubilised or lipid-reconstituted respiratory type II NADH dehydrogenase activity obtained by compound library screening |
title_fullStr |
Annotated compound data for modulators of detergent-solubilised or lipid-reconstituted respiratory type II NADH dehydrogenase activity obtained by compound library screening |
title_full_unstemmed |
Annotated compound data for modulators of detergent-solubilised or lipid-reconstituted respiratory type II NADH dehydrogenase activity obtained by compound library screening |
title_sort |
annotated compound data for modulators of detergent-solubilised or lipid-reconstituted respiratory type ii nadh dehydrogenase activity obtained by compound library screening |
publisher |
Elsevier |
series |
Data in Brief |
issn |
2352-3409 |
publishDate |
2016-03-01 |
description |
The energy-generating membrane protein NADH dehydrogenase (NDH-2), a proposed antibacterial drug target (see “Inhibitors of type II NADH:menaquinone oxidoreductase represent a class of antitubercular drugs” Weinstein et al. 2005 [1]), was screened for modulators of activity in either detergent-solublised or lipid reconstituted (proteolipsome) form. Here we present an annotated list of compounds identified in a small-scale screen against NDH-2. The dataset contains information regarding the libraries screened, the identities of hit compounds and the physicochemical properties governing solubility and permeability. The implications of these data for future antibiotic discovery are discussed in our associated report, “Comparison of lipid and detergent enzyme environments for identifying inhibitors of membrane-bound energy-transducing proteins” [2]. |
url |
http://www.sciencedirect.com/science/article/pii/S2352340915003856 |
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