Mutations in Craniosynostosis Patients Cause Defective Interleukin-11 Receptor Maturation and Drive Craniosynostosis-like Disease in Mice

Mutations in Craniosynostosis Patients Cause Defective Interleukin-11 Receptor Maturation and Drive Craniosynostosis-like Disease in Mice

Summary: Premature closure of the sutures that connect the cranial bones during development of the mammalian skull results in a phenotype called craniosynostosis. Recently, several craniosynostosis patients with missense mutations within the gene encoding the interleukin-11 receptor (IL-11R) have be...

Full description

Bibliographic Details
Main Authors: Maria Agthe, Julian Brügge, Yvonne Garbers, Marieke Wandel, Birte Kespohl, Philipp Arnold, Charlotte M. Flynn, Juliane Lokau, Samadhi Aparicio-Siegmund, Christian Bretscher, Stefan Rose-John, Georg H. Waetzig, Tracy Putoczki, Joachim Grötzinger, Christoph Garbers
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718314207

Internet

http://www.sciencedirect.com/science/article/pii/S2211124718314207

Similar Items