A Time-Course Comparison of Skeletal Muscle Metabolomic Alterations in Walker-256 Tumour-Bearing Rats at Different Stages of Life
Cancer cachexia is a severe wasting condition that needs further study to find ways to minimise the effects of damage and poor prognosis. Skeletal muscle is the most impacted tissue in cancer cachexia; thus, elucidation of its metabolic alterations could provide a direct clue for biomarker research...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-06-01
|
Series: | Metabolites |
Subjects: | |
Online Access: | https://www.mdpi.com/2218-1989/11/6/404 |
id |
doaj-a5e14573353c4cfda4052b4687be37f8 |
---|---|
record_format |
Article |
spelling |
doaj-a5e14573353c4cfda4052b4687be37f82021-07-01T00:40:29ZengMDPI AGMetabolites2218-19892021-06-011140440410.3390/metabo11060404A Time-Course Comparison of Skeletal Muscle Metabolomic Alterations in Walker-256 Tumour-Bearing Rats at Different Stages of LifeGabriela de Matuoka e Chiocchetti0Leisa Lopes-Aguiar1Natália Angelo da Silva Miyaguti2Lais Rosa Viana3Carla de Moraes Salgado4Ophelie Ocean Orvoën5Derly Florindo6Rogério Williams dos Santos7Maria Cristina Cintra Gomes-Marcondes8Laboratory of Nutrition and Cancer, Department of Structural and Functional Biology, Biology Institute, University of Campinas (UNICAMP), Rua Monteiro Lobato, 255, Campinas 13083862, SP, BrazilLaboratory of Nutrition and Cancer, Department of Structural and Functional Biology, Biology Institute, University of Campinas (UNICAMP), Rua Monteiro Lobato, 255, Campinas 13083862, SP, BrazilLaboratory of Nutrition and Cancer, Department of Structural and Functional Biology, Biology Institute, University of Campinas (UNICAMP), Rua Monteiro Lobato, 255, Campinas 13083862, SP, BrazilLaboratory of Nutrition and Cancer, Department of Structural and Functional Biology, Biology Institute, University of Campinas (UNICAMP), Rua Monteiro Lobato, 255, Campinas 13083862, SP, BrazilLaboratory of Nutrition and Cancer, Department of Structural and Functional Biology, Biology Institute, University of Campinas (UNICAMP), Rua Monteiro Lobato, 255, Campinas 13083862, SP, BrazilLaboratory of Nutrition and Cancer, Department of Structural and Functional Biology, Biology Institute, University of Campinas (UNICAMP), Rua Monteiro Lobato, 255, Campinas 13083862, SP, BrazilLaboratory of Nutrition and Cancer, Department of Structural and Functional Biology, Biology Institute, University of Campinas (UNICAMP), Rua Monteiro Lobato, 255, Campinas 13083862, SP, BrazilLaboratory of Nutrition and Cancer, Department of Structural and Functional Biology, Biology Institute, University of Campinas (UNICAMP), Rua Monteiro Lobato, 255, Campinas 13083862, SP, BrazilLaboratory of Nutrition and Cancer, Department of Structural and Functional Biology, Biology Institute, University of Campinas (UNICAMP), Rua Monteiro Lobato, 255, Campinas 13083862, SP, BrazilCancer cachexia is a severe wasting condition that needs further study to find ways to minimise the effects of damage and poor prognosis. Skeletal muscle is the most impacted tissue in cancer cachexia; thus, elucidation of its metabolic alterations could provide a direct clue for biomarker research and be applied to detect this syndrome earlier. In addition, concerning the significant changes in the host metabolism across life, this study aimed to compare the metabolic muscle changes in cachectic tumour-bearing hosts at different ages. We performed <sup>1</sup>H-NMR metabolomics in the gastrocnemius muscle in weanling and young adult Walker-256 tumour-bearing rats at different stages of tumour evolution (initial, intermediate, and advanced). Among the 49 metabolites identified, 24 were significantly affected throughout tumour evolution and 21 were significantly affected regarding animal age. The altered metabolites were mainly related to increased amino acid levels and changed energetic metabolism in the skeletal muscle, suggesting an expressive catabolic process and diverted energy production, especially in advanced tumour stages in both groups. Moreover, these changes were more severe in weanling hosts throughout tumour evolution, suggesting the distinct impact of cancer cachexia regarding the host’s age, highlighting the need to adopting the right animal age when studying cancer cachexia.https://www.mdpi.com/2218-1989/11/6/404cachexiametabolomicsskeletal muscletime-courseWalker-256 tumour |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gabriela de Matuoka e Chiocchetti Leisa Lopes-Aguiar Natália Angelo da Silva Miyaguti Lais Rosa Viana Carla de Moraes Salgado Ophelie Ocean Orvoën Derly Florindo Rogério Williams dos Santos Maria Cristina Cintra Gomes-Marcondes |
spellingShingle |
Gabriela de Matuoka e Chiocchetti Leisa Lopes-Aguiar Natália Angelo da Silva Miyaguti Lais Rosa Viana Carla de Moraes Salgado Ophelie Ocean Orvoën Derly Florindo Rogério Williams dos Santos Maria Cristina Cintra Gomes-Marcondes A Time-Course Comparison of Skeletal Muscle Metabolomic Alterations in Walker-256 Tumour-Bearing Rats at Different Stages of Life Metabolites cachexia metabolomics skeletal muscle time-course Walker-256 tumour |
author_facet |
Gabriela de Matuoka e Chiocchetti Leisa Lopes-Aguiar Natália Angelo da Silva Miyaguti Lais Rosa Viana Carla de Moraes Salgado Ophelie Ocean Orvoën Derly Florindo Rogério Williams dos Santos Maria Cristina Cintra Gomes-Marcondes |
author_sort |
Gabriela de Matuoka e Chiocchetti |
title |
A Time-Course Comparison of Skeletal Muscle Metabolomic Alterations in Walker-256 Tumour-Bearing Rats at Different Stages of Life |
title_short |
A Time-Course Comparison of Skeletal Muscle Metabolomic Alterations in Walker-256 Tumour-Bearing Rats at Different Stages of Life |
title_full |
A Time-Course Comparison of Skeletal Muscle Metabolomic Alterations in Walker-256 Tumour-Bearing Rats at Different Stages of Life |
title_fullStr |
A Time-Course Comparison of Skeletal Muscle Metabolomic Alterations in Walker-256 Tumour-Bearing Rats at Different Stages of Life |
title_full_unstemmed |
A Time-Course Comparison of Skeletal Muscle Metabolomic Alterations in Walker-256 Tumour-Bearing Rats at Different Stages of Life |
title_sort |
time-course comparison of skeletal muscle metabolomic alterations in walker-256 tumour-bearing rats at different stages of life |
publisher |
MDPI AG |
series |
Metabolites |
issn |
2218-1989 |
publishDate |
2021-06-01 |
description |
Cancer cachexia is a severe wasting condition that needs further study to find ways to minimise the effects of damage and poor prognosis. Skeletal muscle is the most impacted tissue in cancer cachexia; thus, elucidation of its metabolic alterations could provide a direct clue for biomarker research and be applied to detect this syndrome earlier. In addition, concerning the significant changes in the host metabolism across life, this study aimed to compare the metabolic muscle changes in cachectic tumour-bearing hosts at different ages. We performed <sup>1</sup>H-NMR metabolomics in the gastrocnemius muscle in weanling and young adult Walker-256 tumour-bearing rats at different stages of tumour evolution (initial, intermediate, and advanced). Among the 49 metabolites identified, 24 were significantly affected throughout tumour evolution and 21 were significantly affected regarding animal age. The altered metabolites were mainly related to increased amino acid levels and changed energetic metabolism in the skeletal muscle, suggesting an expressive catabolic process and diverted energy production, especially in advanced tumour stages in both groups. Moreover, these changes were more severe in weanling hosts throughout tumour evolution, suggesting the distinct impact of cancer cachexia regarding the host’s age, highlighting the need to adopting the right animal age when studying cancer cachexia. |
topic |
cachexia metabolomics skeletal muscle time-course Walker-256 tumour |
url |
https://www.mdpi.com/2218-1989/11/6/404 |
work_keys_str_mv |
AT gabrieladematuokaechiocchetti atimecoursecomparisonofskeletalmusclemetabolomicalterationsinwalker256tumourbearingratsatdifferentstagesoflife AT leisalopesaguiar atimecoursecomparisonofskeletalmusclemetabolomicalterationsinwalker256tumourbearingratsatdifferentstagesoflife AT nataliaangelodasilvamiyaguti atimecoursecomparisonofskeletalmusclemetabolomicalterationsinwalker256tumourbearingratsatdifferentstagesoflife AT laisrosaviana atimecoursecomparisonofskeletalmusclemetabolomicalterationsinwalker256tumourbearingratsatdifferentstagesoflife AT carlademoraessalgado atimecoursecomparisonofskeletalmusclemetabolomicalterationsinwalker256tumourbearingratsatdifferentstagesoflife AT ophelieoceanorvoen atimecoursecomparisonofskeletalmusclemetabolomicalterationsinwalker256tumourbearingratsatdifferentstagesoflife AT derlyflorindo atimecoursecomparisonofskeletalmusclemetabolomicalterationsinwalker256tumourbearingratsatdifferentstagesoflife AT rogeriowilliamsdossantos atimecoursecomparisonofskeletalmusclemetabolomicalterationsinwalker256tumourbearingratsatdifferentstagesoflife AT mariacristinacintragomesmarcondes atimecoursecomparisonofskeletalmusclemetabolomicalterationsinwalker256tumourbearingratsatdifferentstagesoflife AT gabrieladematuokaechiocchetti timecoursecomparisonofskeletalmusclemetabolomicalterationsinwalker256tumourbearingratsatdifferentstagesoflife AT leisalopesaguiar timecoursecomparisonofskeletalmusclemetabolomicalterationsinwalker256tumourbearingratsatdifferentstagesoflife AT nataliaangelodasilvamiyaguti timecoursecomparisonofskeletalmusclemetabolomicalterationsinwalker256tumourbearingratsatdifferentstagesoflife AT laisrosaviana timecoursecomparisonofskeletalmusclemetabolomicalterationsinwalker256tumourbearingratsatdifferentstagesoflife AT carlademoraessalgado timecoursecomparisonofskeletalmusclemetabolomicalterationsinwalker256tumourbearingratsatdifferentstagesoflife AT ophelieoceanorvoen timecoursecomparisonofskeletalmusclemetabolomicalterationsinwalker256tumourbearingratsatdifferentstagesoflife AT derlyflorindo timecoursecomparisonofskeletalmusclemetabolomicalterationsinwalker256tumourbearingratsatdifferentstagesoflife AT rogeriowilliamsdossantos timecoursecomparisonofskeletalmusclemetabolomicalterationsinwalker256tumourbearingratsatdifferentstagesoflife AT mariacristinacintragomesmarcondes timecoursecomparisonofskeletalmusclemetabolomicalterationsinwalker256tumourbearingratsatdifferentstagesoflife |
_version_ |
1721347991571267584 |