Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism

Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism

Antibiotic-induced microbiome depletion is one of the most common approaches to modulate the gut microbiome. Here the authors demonstrate that it affects gut homeostasis and glucose metabolism by decreasing luminal short chain fatty acids and leading to a shift of energy utilization by colonocytes.

Bibliographic Details
Main Authors: Amir Zarrinpar, Amandine Chaix, Zhenjiang Z. Xu, Max W. Chang, Clarisse A. Marotz, Alan Saghatelian, Rob Knight, Satchidananda Panda
Format: Article
Language:English
Published: Nature Publishing Group 2018-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05336-9
id doaj-a5e2a93dd23c4ffd9f9cfa80ad8db294
record_format Article
spelling doaj-a5e2a93dd23c4ffd9f9cfa80ad8db2942021-01-31T14:29:56ZengNature Publishing GroupNature Communications2041-17232018-07-019111310.1038/s41467-018-05336-9Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolismAmir Zarrinpar0Amandine Chaix1Zhenjiang Z. Xu2Max W. Chang3Clarisse A. Marotz4Alan Saghatelian5Rob Knight6Satchidananda Panda7Regulatory Biology Laboratory, The Salk InstituteRegulatory Biology Laboratory, The Salk InstituteCenter for Microbiome Innovation, University of California, San DiegoIntegrative Genomics and Bioinformatics Core, The Salk InstituteCenter for Microbiome Innovation, University of California, San DiegoProtein Biology Laboratory, The Salk InstituteCenter for Microbiome Innovation, University of California, San DiegoRegulatory Biology Laboratory, The Salk InstituteAntibiotic-induced microbiome depletion is one of the most common approaches to modulate the gut microbiome. Here the authors demonstrate that it affects gut homeostasis and glucose metabolism by decreasing luminal short chain fatty acids and leading to a shift of energy utilization by colonocytes.https://doi.org/10.1038/s41467-018-05336-9
collection DOAJ
language English
format Article
sources DOAJ
author Amir Zarrinpar
Amandine Chaix
Zhenjiang Z. Xu
Max W. Chang
Clarisse A. Marotz
Alan Saghatelian
Rob Knight
Satchidananda Panda
spellingShingle Amir Zarrinpar
Amandine Chaix
Zhenjiang Z. Xu
Max W. Chang
Clarisse A. Marotz
Alan Saghatelian
Rob Knight
Satchidananda Panda
Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism
Nature Communications
author_facet Amir Zarrinpar
Amandine Chaix
Zhenjiang Z. Xu
Max W. Chang
Clarisse A. Marotz
Alan Saghatelian
Rob Knight
Satchidananda Panda
author_sort Amir Zarrinpar
title Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism
title_short Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism
title_full Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism
title_fullStr Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism
title_full_unstemmed Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism
title_sort antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-07-01
description Antibiotic-induced microbiome depletion is one of the most common approaches to modulate the gut microbiome. Here the authors demonstrate that it affects gut homeostasis and glucose metabolism by decreasing luminal short chain fatty acids and leading to a shift of energy utilization by colonocytes.
url https://doi.org/10.1038/s41467-018-05336-9
work_keys_str_mv AT amirzarrinpar antibioticinducedmicrobiomedepletionaltersmetabolichomeostasisbyaffectinggutsignalingandcolonicmetabolism
AT amandinechaix antibioticinducedmicrobiomedepletionaltersmetabolichomeostasisbyaffectinggutsignalingandcolonicmetabolism
AT zhenjiangzxu antibioticinducedmicrobiomedepletionaltersmetabolichomeostasisbyaffectinggutsignalingandcolonicmetabolism
AT maxwchang antibioticinducedmicrobiomedepletionaltersmetabolichomeostasisbyaffectinggutsignalingandcolonicmetabolism
AT clarisseamarotz antibioticinducedmicrobiomedepletionaltersmetabolichomeostasisbyaffectinggutsignalingandcolonicmetabolism
AT alansaghatelian antibioticinducedmicrobiomedepletionaltersmetabolichomeostasisbyaffectinggutsignalingandcolonicmetabolism
AT robknight antibioticinducedmicrobiomedepletionaltersmetabolichomeostasisbyaffectinggutsignalingandcolonicmetabolism
AT satchidanandapanda antibioticinducedmicrobiomedepletionaltersmetabolichomeostasisbyaffectinggutsignalingandcolonicmetabolism
_version_ 1724316982429351936

Similar Items