Influence Factors on the Hepatotoxicity of Polygoni Multiflori Radix
Background. Chinese herbal medicine (CHM) with reported hepatotoxicity is identified, in which Polygoni Multiflori Radix (HSW) attracts most attention. According to the Traditional Chinese Medicine (TCM) theory, processing is believed to be able to reduce the toxicity of HSW, but in publications, bo...
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Series: | Evidence-Based Complementary and Alternative Medicine |
Online Access: | http://dx.doi.org/10.1155/2019/5482896 |
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doaj-a5e8e77292a04971a15dc2310807ed532020-11-24T21:46:41ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882019-01-01201910.1155/2019/54828965482896Influence Factors on the Hepatotoxicity of Polygoni Multiflori RadixYun Wei0Meixia Liu1Jiangang Liu2Hao Li3Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, ChinaXiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, ChinaXiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, ChinaXiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, ChinaBackground. Chinese herbal medicine (CHM) with reported hepatotoxicity is identified, in which Polygoni Multiflori Radix (HSW) attracts most attention. According to the Traditional Chinese Medicine (TCM) theory, processing is believed to be able to reduce the toxicity of HSW, but in publications, both processed and unprocessed HSW are reported to cause liver injury. Methods. This article reviews the case reports and experimental researches involving liver damage associated with HSW from the following aspects: clinical features, hepatic toxicity components, hepatotoxicity mechanism, and so on. Results. HSW has hepatotoxicity in different degrees and even leads to death, and the reason is multioriginal. Conclusions. People should be educated to have a broad understanding on ensuring drug use safety and lower drug-induced risks when taking HSW preparations.http://dx.doi.org/10.1155/2019/5482896 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yun Wei Meixia Liu Jiangang Liu Hao Li |
spellingShingle |
Yun Wei Meixia Liu Jiangang Liu Hao Li Influence Factors on the Hepatotoxicity of Polygoni Multiflori Radix Evidence-Based Complementary and Alternative Medicine |
author_facet |
Yun Wei Meixia Liu Jiangang Liu Hao Li |
author_sort |
Yun Wei |
title |
Influence Factors on the Hepatotoxicity of Polygoni Multiflori Radix |
title_short |
Influence Factors on the Hepatotoxicity of Polygoni Multiflori Radix |
title_full |
Influence Factors on the Hepatotoxicity of Polygoni Multiflori Radix |
title_fullStr |
Influence Factors on the Hepatotoxicity of Polygoni Multiflori Radix |
title_full_unstemmed |
Influence Factors on the Hepatotoxicity of Polygoni Multiflori Radix |
title_sort |
influence factors on the hepatotoxicity of polygoni multiflori radix |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2019-01-01 |
description |
Background. Chinese herbal medicine (CHM) with reported hepatotoxicity is identified, in which Polygoni Multiflori Radix (HSW) attracts most attention. According to the Traditional Chinese Medicine (TCM) theory, processing is believed to be able to reduce the toxicity of HSW, but in publications, both processed and unprocessed HSW are reported to cause liver injury. Methods. This article reviews the case reports and experimental researches involving liver damage associated with HSW from the following aspects: clinical features, hepatic toxicity components, hepatotoxicity mechanism, and so on. Results. HSW has hepatotoxicity in different degrees and even leads to death, and the reason is multioriginal. Conclusions. People should be educated to have a broad understanding on ensuring drug use safety and lower drug-induced risks when taking HSW preparations. |
url |
http://dx.doi.org/10.1155/2019/5482896 |
work_keys_str_mv |
AT yunwei influencefactorsonthehepatotoxicityofpolygonimultifloriradix AT meixialiu influencefactorsonthehepatotoxicityofpolygonimultifloriradix AT jiangangliu influencefactorsonthehepatotoxicityofpolygonimultifloriradix AT haoli influencefactorsonthehepatotoxicityofpolygonimultifloriradix |
_version_ |
1725900651517444096 |