Deregulation of a Network of mRNA and miRNA Genes Reveals That CK2 and MEK Inhibitors May Synergize to Induce Apoptosis KRAS-Active NSCLC

Deregulation of a Network of mRNA and miRNA Genes Reveals That CK2 and MEK Inhibitors May Synergize to Induce Apoptosis KRAS-Active NSCLC

KRAS-activation mutations occur in 25% to 40% of lung adenocarcinomas and are a known mechanism of epidermal growth factor receptor inhibitor (EGFRI) resistance. There are currently no targeted therapies approved specifically for the treatment of KRAS-active non–small cell lung cancers (NSCLC). Atte...

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Bibliographic Details
Main Authors: Madeline Krentz Gober, Robert M Flight, Joshua Lambert, Hunter Moseley, Arnold Stromberg, Esther P Black
Format: Article
Language:English
Published: SAGE Publishing 2019-05-01
Series:Cancer Informatics
Online Access:https://doi.org/10.1177/1176935119843507

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